Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
aging
cardiovascular
inflammation
senescence
smooth muscle cell
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
03
2020
accepted:
27
04
2020
entrez:
12
6
2020
pubmed:
12
6
2020
medline:
12
6
2020
Statut:
epublish
Résumé
The senescence of vascular smooth muscle cells (VSMCs) has been implicated as a causal pro-inflammatory mechanism for cardiovascular disease development and progression of atherosclerosis, the instigator of ischemic heart disease. Contemporary limitations related to studying this cellular population and senescence-related therapeutics are caused by a lack of specific markers enabling their detection. Therefore, we aimed to profile a phenotypical and molecular signature of senescent VSMCs to allow reliable identification. To achieve this goal, we have compared non-senescent and senescent VSMCs from two
Identifiants
pubmed: 32523550
doi: 10.3389/fphys.2020.00520
pmc: PMC7261939
doi:
Types de publication
Journal Article
Langues
eng
Pagination
520Informations de copyright
Copyright © 2020 Stojanović, Fuchs, Kunz, Xiao, Just, Pich, Bauersachs, Fiedler, Sedding and Thum.
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