Sustained adenosine exposure causes endothelial mitochondrial dysfunction via equilibrative nucleoside transporters.
adenosine
endothelial cells
equilibrative nucleoside transporter (ENT)1/2
mitochondrial fission
mitochondrial respiration
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Historique:
received:
21
02
2020
accepted:
16
04
2020
entrez:
12
6
2020
pubmed:
12
6
2020
medline:
12
6
2020
Statut:
epublish
Résumé
Adenosine is a potent signaling molecule that has paradoxical effects on lung diseases. We have previously demonstrated that sustained adenosine exposure by inhibition of adenosine degradation impairs lung endothelial barrier integrity and causes intrinsic apoptosis through equilibrative nucleoside transporter
Identifiants
pubmed: 32523687
doi: 10.1177/2045894020924994
pii: 10.1177_2045894020924994
pmc: PMC7235668
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2045894020924994Informations de copyright
© The Author(s) 2020.
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