A novel social fear conditioning procedure alters social behavior and mTOR signaling in differentially housed adolescent rats.
animal
escape reaction
models
post-traumatic
prefrontal cortex
ribosomal protein S6
social behavior
social isolation
stress disorders
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
12
11
2019
revised:
07
04
2020
accepted:
30
04
2020
pubmed:
12
6
2020
medline:
15
12
2021
entrez:
12
6
2020
Statut:
ppublish
Résumé
Vulnerabilities to fear-related disorders can be enhanced following early life adversity. This study sought to determine whether post-weaning social isolation (PSI), an animal model of early life adversity, alters the development of social fear in an innovative model of conditioned social fear. Male and female Sprague-Dawley rats underwent either social rearing (SR) or PSI for 4 weeks following weaning. Rats were then assigned to groups consisting of either Footshock only, Social conditioned stimulus (CS) only, or Paired footshock with a social CS. Social behavior was assessed the next day. We observed a novel behavioral response in PSI rats, running in circles, that was rarely observed in SR rats; moreover, this behavior was augmented after Paired treatment in PSI rats. Other social behaviors were altered by both PSI and Paired footshock and social CS. The mammalian target of rapamycin (mTOR) pathway was assessed using immunohistochemistry for phosphorylated ribosomal protein S6 (pS6) in subregions of the prefrontal cortex (PFC) and amygdala. Paired treatment produced opposite effects in the PFC and amygdala in males, but no differences were observed in females. Conditioned social fear produced alterations in social behavior and the mTOR pathway that are dependent upon rearing condition and sex.
Identifiants
pubmed: 32524583
doi: 10.1002/dev.22001
pmc: PMC7726006
mid: NIHMS1614304
doi:
Substances chimiques
mTOR protein, rat
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-87Subventions
Organisme : NIMH NIH HHS
ID : R15 MH102717
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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