Proinflammatory Cytokines in the Olfactory Mucosa Result in COVID-19 Induced Anosmia.
Anosmia
COVID-19
Inflammation
Tumor necrosis factor-alpha
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
pubmed:
12
6
2020
medline:
16
7
2020
entrez:
12
6
2020
Statut:
ppublish
Résumé
Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease 2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The primary objective of this study was to explore local proinflammatory cytokine levels in the olfactory epithelium in patients with COVID-19. Biopsies of the olfactory epithelium were taken from patients with confirmed COVID-19 as well as uninfected controls. Levels of tumor necrosis factor α (TNF-α) and interleukin-1-beta (IL-1β) were assessed using ELISA and compared between groups. Average TNF-α levels were significantly increased in the olfactory epithelium of the COVID-19 group compared to the control group (
Identifiants
pubmed: 32525657
doi: 10.1021/acschemneuro.0c00249
doi:
Substances chimiques
Cytokines
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM