Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort.
Journal
PLoS genetics
ISSN: 1553-7404
Titre abrégé: PLoS Genet
Pays: United States
ID NLM: 101239074
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
07
01
2020
accepted:
22
04
2020
entrez:
12
6
2020
pubmed:
12
6
2020
medline:
18
8
2020
Statut:
epublish
Résumé
Recent discoveries from large-scale genome-wide association studies (GWASs) explain a larger proportion of the genetic variability to BMI and obesity. The genetic risk associated with BMI and obesity can be assessed by an obesity-specific genetic risk score (GRS) constructed from genome-wide significant genetic variants. The aim of our study is to examine whether the duration and exclusivity of breastfeeding can attenuate BMI increase during childhood and adolescence due to genetic risks. A total sample of 5,266 children (2,690 boys and 2,576 girls) from the Avon Longitudinal Study of Parents and Children (ALSPAC) was used for the analysis. We evaluated the role of breastfeeding (exclusivity and duration) in modulating BMI increase attributed to the GRS from birth to 18 years of age. The GRS was composed of 69 variants associated with adult BMI and 25 non-overlapping SNPs associated with pediatric BMI. In the high genetic susceptible group (upper GRS quartile), exclusive breastfeeding (EBF) to 5 months reduces BMI by 1.14 kg/m2 (95% CI, 0.37 to 1.91, p = 0.0037) in 18-year-old boys, which compensates a 3.9-decile GRS increase. In 18-year-old girls, EBF to 5 months decreases BMI by 1.53 kg/m2 (95% CI, 0.76 to 2.29, p<0.0001), which compensates a 7.0-decile GRS increase. EBF acts early in life by delaying the age at adiposity peak and at adiposity rebound. EBF to 3 months or non-exclusive breastfeeding was associated with a significantly diminished impact on reducing BMI growth during childhood. EBF influences early life growth and development and thus may play a critical role in preventing overweight and obesity among children at high-risk due to genetic factors.
Identifiants
pubmed: 32525877
doi: 10.1371/journal.pgen.1008790
pii: PGENETICS-D-20-00028
pmc: PMC7289340
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1008790Subventions
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NIMHD NIH HHS
ID : U54 MD007601
Pays : United States
Organisme : Wellcome Trust
ID : 102215/2/13/2
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
JAMA Pediatr. 2014 Dec;168(12):1122-30
pubmed: 25329327
Int J Obes (Lond). 2019 Oct;43(10):2007-2016
pubmed: 31332278
Rev Obstet Gynecol. 2009 Fall;2(4):222-31
pubmed: 20111658
Chembiochem. 2015 Jan 19;16(2):195-203
pubmed: 25469751
N Engl J Med. 2018 Oct 04;379(14):1303-1312
pubmed: 30281992
Pediatr Obes. 2018 Mar;13(3):133-140
pubmed: 28008729
Nat Commun. 2019 Oct 1;10(1):4448
pubmed: 31575865
Diabetes. 2018 Feb;67(2):248-255
pubmed: 29212779
Sci Adv. 2019 Sep 04;5(9):eaaw3095
pubmed: 31840077
Nutr Metab Insights. 2016 Mar 20;8(Suppl 1):49-56
pubmed: 27013888
Am J Clin Nutr. 1993 Aug;58(2):152-61
pubmed: 8338041
Lancet. 2016 Jan 30;387(10017):491-504
pubmed: 26869576
Int J Epidemiol. 2017 Oct 1;46(5):1512-1522
pubmed: 29040503
Hum Mol Genet. 2018 Oct 15;27(20):3641-3649
pubmed: 30124842
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Int J Epidemiol. 2017 Apr 1;46(2):559-575
pubmed: 28073954
Am J Epidemiol. 2005 Sep 1;162(5):397-403
pubmed: 16076830
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
J Epidemiol Community Health. 2004 Feb;58(2):114-5
pubmed: 14729887
PLoS One. 2013 Nov 11;8(11):e79547
pubmed: 24244521
Reprod Nutr Dev. 2002 Mar-Apr;42(2):133-47
pubmed: 12216959
Obes Facts. 2019;12(2):226-243
pubmed: 31030194
Arch Pediatr Adolesc Med. 2012 Jun 1;166(6):515-21
pubmed: 22665028
Int J Obes (Lond). 2020 May 18;:
pubmed: 32424267
JAMA Pediatr. 2016 Feb;170(2):e154472
pubmed: 26830872
Nat Rev Genet. 2018 Sep;19(9):581-590
pubmed: 29789686
J Transl Med. 2015 Dec 21;13:385
pubmed: 26691922
Eur J Epidemiol. 2009;24(8):449-67
pubmed: 19521784
Cell. 2019 Apr 18;177(3):587-596.e9
pubmed: 31002795
Nature. 2015 Feb 12;518(7538):197-206
pubmed: 25673413
BMC Genet. 2016 Aug 18;17(1):120
pubmed: 27538985
Pediatr Obes. 2019 Mar;14(3):e12479
pubmed: 30515969
Am J Clin Nutr. 1984 Jan;39(1):129-35
pubmed: 6691287