Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom.

Animals Coral Snakes / genetics Elapid Venoms / toxicity Elapidae Mice Neurotoxins / toxicity Phospholipases A2 Proteomics Transcriptome
Micrurus browni Multimeric neurotoxin Neuromuscular blockers Phospholipases A(2) Prey specificity Proteome Three-finger toxins

Journal

Journal of proteomics
ISSN: 1876-7737
Titre abrégé: J Proteomics
Pays: Netherlands
ID NLM: 101475056

Informations de publication

Date de publication:
15 08 2020
Historique:
received: 04 04 2020
revised: 18 05 2020
accepted: 04 06 2020
pubmed: 12 6 2020
medline: 22 6 2021
entrez: 12 6 2020
Statut: ppublish

Résumé

Proteomic characterization of Micrurus browni browni venom showed approximately 41 components belonging to 9 protein families, mainly phospholipases A

Identifiants

DOI: 10.1016/j.jprot.2020.103863 PMID: 32526478
pubmed: 32526478
pii: S1874-3919(20)30231-1
doi: 10.1016/j.jprot.2020.103863
pii:
doi:

Substances chimiques

Elapid Venoms 0
Neurotoxins 0
Phospholipases A2 EC 3.1.1.4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103863

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest regarding the present work.

Auteurs

Melisa Bénard-Valle (M)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico. Electronic address: mel@ibt.unam.mx.

Edgar Neri-Castro (E)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico.

Manuel F Yañez-Mendoza (MF)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico; Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Mexico.

Bruno Lomonte (B)

Facultad de Microbiología, Instituto Clodomiro Picado, Universidad de Costa Rica, Costa Rica.

Alejandro Olvera (A)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico.

Fernando Zamudio (F)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico.

Rita Restano-Cassulini (R)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico.

Lourival D Possani (LD)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico.

Enrique Jiménez-Ferrer (E)

Centro de Investigaciones Biomédicas del Sur, Instituto Mexicano del Seguro Social, Mexico.

Alejandro Alagón (A)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Colonia Chamilpa, CP: 62210 Cuernavaca, Morelos, Mexico.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Reptiles › Serpents › Alethinophidia › Elapidae › Serpents corail › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de serpent › Venins des élapidés › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Reptiles › Serpents › Alethinophidia › Elapidae › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Neurotoxines › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Phospholipases A › Phospholipases A2 › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Functional, proteomic and transcriptomic...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Functional, proteomic and transcriptomic...