Acute Myeloid Leukemia with t(6;9)(p23;q34.1); DEK-NUP214: The Pathogenesis and Potential.

Journal

Journal of the Association of Genetic Technologists
ISSN: 1523-7834
Titre abrégé: J Assoc Genet Technol
Pays: United States
ID NLM: 9807282

Informations de publication

Date de publication:
2020
Historique:
received: 09 06 2020
accepted: 09 06 2020
entrez: 12 6 2020
pubmed: 12 6 2020
medline: 12 6 2020
Statut: ppublish

Résumé

Acute myeloid leukemia (AML) is caused by the arrested differentiation and dysregulated proliferation of myeloid precursors. Many AMLs harbor genetic abnormalities which determine the molecular mechanisms of the disease and are associated with distinct clinical and pathological features, prognosis, and targeted therapies. We present a case of acute myeloid leukemia with t(6;9)(p23;q34.1) and review the classic clinical presentations and underlying pathogenesis of the disease.

Identifiants

PMID: 32526729
pubmed: 32526729

Types de publication

Journal Article

Langues

eng

Pagination

98-102

Informations de copyright

Copyright© by the Association of Genetic Technologists.

Auteurs

Juli-Anne Gardner (JA)

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Liam Donnelly (L)

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Rebecca Goetz (R)

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Brianna Waller (B)

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Katherine Devitt (K)

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Classifications MeSH