Prebiotic Therapy with Inulin Associated with Low Protein Diet in Chronic Kidney Disease Patients: Evaluation of Nutritional, Cardiovascular and Psychocognitive Parameters.
Affect
Aged
Biomarkers
/ blood
Cardiovascular Diseases
/ diagnosis
Case-Control Studies
Cognition
Diet, Protein-Restricted
Female
Functional Status
Humans
Inulin
/ therapeutic use
Male
Mental Health
Middle Aged
Nutritional Status
Prebiotics
Prospective Studies
Quality of Life
Renal Insufficiency, Chronic
/ diagnosis
Time Factors
Treatment Outcome
cardiovascular risk
chronic kidney disease
inulin
low protein diet
metabolic profile
microbiota
psychocognitive evaluation
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
09 06 2020
09 06 2020
Historique:
received:
07
04
2020
revised:
02
06
2020
accepted:
03
06
2020
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
3
3
2021
Statut:
epublish
Résumé
A relationship between dysbiotic gut microbiome and chronic kidney disease (CKD) has been recently documented; it contributes to CKD-related complications, including cardiovascular disease. Aim: We tested how a low-protein diet (LPD)-with or without oral inulin supplementation as a prebiotic-modulates some inflammatory, atherosclerosis and endothelial dysfunction indices and nutritional markers, as well as psychocognitive functions in CKD patients. We conducted a prospective, case-control study on CKD patients on conservative therapy, divided in two groups: the intervention group treated with LPD (0.6 g/kg/day) plus inulin (19 g/day) and a control group treated with LPD without inulin, for six consecutive months. Clinical and hematochemical parameters as well as instrumental, and psychocognitive assessments (by SF-36 survey and MMSE, HAM-D, BDI-II) were recorded in all the participants at baseline (T0), at three months (T1) and at six months (T2). A total of 41 patients were enrolled: 18 in the intervention group and 23 in the control group. At T2, in both groups, we observed a significant reduction of serum nitrogen and phosphorus (
Identifiants
pubmed: 32526852
pii: toxins12060381
doi: 10.3390/toxins12060381
pmc: PMC7354587
pii:
doi:
Substances chimiques
Biomarkers
0
Prebiotics
0
Inulin
9005-80-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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