PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy.

Animals Carcinogenesis Humans Neoplasms / metabolism Promyelocytic Leukemia Protein / metabolism
PML nuclear body biogenesis PML-driven carcinogenesis genome oligomerization organization phase separation targeted therapy

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
10 2020
Historique:
received: 31 01 2020
revised: 20 04 2020
accepted: 11 05 2020
pubmed: 13 6 2020
medline: 23 9 2021
entrez: 13 6 2020
Statut: ppublish

Résumé

Targeted therapy has become increasingly important in cancer therapy. For example, targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective treatment. PML is the core component of super-assembled structures called PML nuclear bodies (NBs). Although this nuclear megaDalton complex was first observed in the 1960s, the mechanism of its assembly remains poorly understood. We review recent breakthroughs in the PML field ranging from a revised assembly mechanism to PML-driven genome organization and carcinogenesis. In addition, we highlight that oncogenic oligomerization might also represent a promising target in the treatment of leukemias and solid tumors.

Identifiants

DOI: 10.1016/j.trecan.2020.05.005 PMID: 32527650
pubmed: 32527650
pii: S2405-8033(20)30160-6
doi: 10.1016/j.trecan.2020.05.005
pii:
doi:

Substances chimiques

Promyelocytic Leukemia Protein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

889-906

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Yuwen Li (Y)

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Xiaodan Ma (X)

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Wenyu Wu (W)

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Zhu Chen (Z)

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: zchen@stn.sh.cn.

Guoyu Meng (G)

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: guoyumeng@shsmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PML Nuclear Body Biogenesis, Carcinogenesis,...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › PML Nuclear Body Biogenesis, Carcinogenesis,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › PML Nuclear Body Biogenesis, Carcinogenesis,...
questionsmedicales.fr › Tumeurs › PML Nuclear Body Biogenesis, Carcinogenesis,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › Protéine de la leucémie promyélocytaire › PML Nuclear Body Biogenesis, Carcinogenesis,...