A treponemal genome from an historic plague victim supports a recent emergence of yaws and its presence in 15
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 06 2020
11 06 2020
Historique:
received:
23
03
2020
accepted:
30
03
2020
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Developments in techniques for identification of pathogen DNA in archaeological samples can expand our resolution of disease detection. Our application of a non-targeted molecular screening tool for the parallel detection of pathogens in historical plague victims from post-medieval Lithuania revealed the presence of more than one active disease in one individual. In addition to Yersinia pestis, we detected and genomically characterized a septic infection of Treponema pallidum pertenue, a subtype of the treponemal disease family recognised as the cause of the tropical disease yaws. Our finding in northern Europe of a disease that is currently restricted to equatorial regions is interpreted within an historical framework of intercontinental trade and potential disease movements. Through this we offer an alternative hypothesis for the history and evolution of the treponemal diseases, and posit that yaws be considered an important contributor to the sudden epidemic of late 15
Identifiants
pubmed: 32528126
doi: 10.1038/s41598-020-66012-x
pii: 10.1038/s41598-020-66012-x
pmc: PMC7290034
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9499Références
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