Considering how biological sex impacts immune responses and COVID-19 outcomes.
Journal
Nature reviews. Immunology
ISSN: 1474-1741
Titre abrégé: Nat Rev Immunol
Pays: England
ID NLM: 101124169
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
accepted:
20
05
2020
pubmed:
13
6
2020
medline:
10
7
2020
entrez:
13
6
2020
Statut:
ppublish
Résumé
A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences may manifest themselves in susceptibility to infection, early pathogenesis, innate viral control, adaptive immune responses or the balance of inflammation and tissue repair in the resolution of infection. We discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity and highlight potential sex differences underlying COVID-19 severity. We propose that sex differences in immunopathogenesis will inform mechanisms of COVID-19, identify points for therapeutic intervention and improve vaccine design and increase vaccine efficacy.
Identifiants
pubmed: 32528136
doi: 10.1038/s41577-020-0348-8
pii: 10.1038/s41577-020-0348-8
pmc: PMC7288618
doi:
Substances chimiques
Interferons
9008-11-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
442-447Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007417
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009110
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG062333
Pays : United States
Références
Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12477-12482
pubmed: 30455317
Blood. 2012 Jan 12;119(2):454-64
pubmed: 22096248
J Immunol. 2017 May 15;198(10):4046-4053
pubmed: 28373583
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):869-74
pubmed: 24367114
Nature. 2020 Jan;577(7790):416-420
pubmed: 31875850
Lancet Infect Dis. 2020 May;20(5):565-574
pubmed: 32213337
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Nature. 2017 Oct 11;550(7675):244-248
pubmed: 29022598
Semin Immunopathol. 2019 Mar;41(2):189-194
pubmed: 30298431
Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5257-8
pubmed: 25902532
Am J Clin Pathol. 2020 May 5;153(6):725-733
pubmed: 32275742
Int J Gen Med. 2014 Aug 20;7:417-23
pubmed: 25187734
Cell. 2018 Nov 29;175(6):1701-1715.e16
pubmed: 30449622
Clin Infect Dis. 2020 Jul 28;71(15):863-865
pubmed: 32232322
J Virol. 2017 Mar 29;91(8):
pubmed: 28179523
Horm Behav. 2017 Feb;88:45-51
pubmed: 27816626
Sci Immunol. 2018 Jan 26;3(19):
pubmed: 29374079
PLoS Pathog. 2016 Sep 15;12(9):e1005840
pubmed: 27631986
J Immunol. 2015 Dec 1;195(11):5327-36
pubmed: 26519527
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Respir Med. 2007 Sep;101(9):1845-63
pubmed: 17544265
J Exp Med. 2009 Jan 16;206(1):99-111
pubmed: 19139166
Anaesth Crit Care Pain Med. 2020 Feb;39(1):35-44
pubmed: 31374365
Philos Trans R Soc Lond B Biol Sci. 2017 Nov 5;372(1733):
pubmed: 28947654
J Immunol. 2004 Aug 15;173(4):2227-30
pubmed: 15294932
Hum Genomics. 2019 Jan 8;13(1):2
pubmed: 30621780
Nat Rev Genet. 2008 Dec;9(12):911-22
pubmed: 19002143
Ann Acad Med Singap. 2006 May;35(5):326-31
pubmed: 16829999
Nat Med. 2009 Aug;15(8):955-9
pubmed: 19597505
J Clin Invest. 2016 Apr 1;126(4):1525-37
pubmed: 26999605
Am J Physiol Endocrinol Metab. 2006 May;290(5):E856-63
pubmed: 16352669
J Immunol. 2017 Mar 1;198(5):1782-1790
pubmed: 28223406
PLoS Pathog. 2016 Feb 18;12(2):e1005374
pubmed: 26891052
Medicine (Baltimore). 2018 Oct;97(42):e12917
pubmed: 30335025
J Trauma. 2011 Oct;71(4):878-83; discussion 883-5
pubmed: 21986736
Cytokine. 2020 Feb;126:154895
pubmed: 31706200
Cell. 2020 May 28;181(5):1016-1035.e19
pubmed: 32413319
JAMA. 2020 Apr 28;323(16):1582-1589
pubmed: 32219428
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7001-7003
pubmed: 32165541
JAMA Intern Med. 2020 Apr 1;180(4):574-583
pubmed: 32040165
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
Immunity. 2020 Jun 16;52(6):910-941
pubmed: 32505227
Intensive Care Med. 2020 May;46(5):846-848
pubmed: 32125452
Cell Immunol. 2020 Feb;348:104024
pubmed: 31843200
PLoS Pathog. 2020 Apr 28;16(4):e1008520
pubmed: 32343745
N Engl J Med. 2020 Aug 27;383(9):804-805
pubmed: 32302079
J Clin Invest. 2002 Jun;109(12):1625-33
pubmed: 12070310
Nat Rev Immunol. 2016 Oct;16(10):626-38
pubmed: 27546235
Mucosal Immunol. 2017 Sep;10(5):1097-1107
pubmed: 28401937
Cancer Discov. 2020 Jun;10(6):779-782
pubmed: 32276929
Annu Rev Cell Dev Biol. 2017 Oct 6;33:577-599
pubmed: 28992436
N Engl J Med. 2020 Dec 17;383(25):2451-2460
pubmed: 32412710
Emerg Microbes Infect. 2012 Sep;1(9):e23
pubmed: 26038429
Trends Immunol. 2014 Mar;35(3):97-104
pubmed: 24239225
J Immunol. 2006 Mar 1;176(5):2703-10
pubmed: 16493025
Genome Res. 2013 Sep;23(9):1474-85
pubmed: 23800453
Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E488-E497
pubmed: 29282317
Genes Immun. 2009 Jul;10(5):509-16
pubmed: 19279650
Nat Commun. 2020 Feb 6;11(1):751
pubmed: 32029736
J Immunol. 2006 Aug 15;177(4):2088-96
pubmed: 16887967
Endocr Rev. 2007 Aug;28(5):521-74
pubmed: 17640948
PLoS One. 2011 Apr 29;6(4):e19409
pubmed: 21559366
Nat Commun. 2016 Apr 13;7:11350
pubmed: 27072778
Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3491-3496
pubmed: 28242695
Lancet. 2020 Jun 6;395(10239):1771-1778
pubmed: 32410760
BMC Infect Dis. 2019 Jan 10;19(1):42
pubmed: 30630435
Biol Sex Differ. 2010 Nov 05;1(1):6
pubmed: 21208466
Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L415-25
pubmed: 26684252
PLoS Pathog. 2020 Jun 22;16(6):e1008570
pubmed: 32569293
Nat Rev Genet. 2007 Sep;8(9):689-98
pubmed: 17680007
Clin Infect Dis. 2020 Jul 28;71(15):799-806
pubmed: 32271376
Am J Surg. 2015 Nov;210(5):911-21
pubmed: 26145388
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2029-38
pubmed: 27001848
Nat Rev Endocrinol. 2013 Jan;9(1):56-62
pubmed: 23183675
J Virol. 2014 May;88(9):4711-20
pubmed: 24522912
Semin Immunopathol. 2019 Mar;41(2):153-164
pubmed: 30276444
Am J Epidemiol. 2004 Feb 1;159(3):229-31
pubmed: 14742282
Cell Syst. 2015 Jul 29;1(1):51-61
pubmed: 26251845
Immunohorizons. 2019 Apr;3(4):121-132
pubmed: 31317126
Nature. 2019 Nov;575(7781):137-146
pubmed: 31695204
J Virol. 2010 Feb;84(3):1289-301
pubmed: 19906920
Proc Natl Acad Sci U S A. 2019 Dec 10;:
pubmed: 31822606
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
J Clin Invest. 2020 Jul 1;130(7):3350-3352
pubmed: 32392184
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
Mol Med. 2011 Mar-Apr;17(3-4):211-20
pubmed: 21107497
J Cell Physiol. 2008 Feb;214(2):456-64
pubmed: 17654501
J Thorac Oncol. 2020 May;15(5):700-704
pubmed: 32114094
Geroscience. 2020 Apr;42(2):505-514
pubmed: 32274617
NPJ Vaccines. 2019 Jul 12;4:29
pubmed: 31312529
Cell Host Microbe. 2020 Jun 10;27(6):992-1000.e3
pubmed: 32320677
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Antiviral Res. 2020 Jun;178:104791
pubmed: 32275914
Biol Sex Differ. 2011 Aug 01;2:8
pubmed: 21806829
Nat Med. 2004 Mar;10(3):290-3
pubmed: 14981511
BMJ. 2020 Apr 21;369:m1443
pubmed: 32317267
Lancet Respir Med. 2020 May;8(5):475-481
pubmed: 32105632
Annu Rev Microbiol. 2012;66:177-96
pubmed: 22994491
Mod Pathol. 2020 Jun;33(6):1007-1014
pubmed: 32291399
J Immunol. 2014 Dec 1;193(11):5444-52
pubmed: 25339659
Front Public Health. 2020 Apr 29;8:152
pubmed: 32411652
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
Science. 2007 Jul 6;317(5834):121-4
pubmed: 17615358
Aging (Albany NY). 2020 Jun 5;12(11):10087-10098
pubmed: 32501810
Cell Rep. 2019 Nov 12;29(7):1961-1973.e4
pubmed: 31722210
Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2703-8
pubmed: 10694576