Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats.
EEG
brain development
ketamine
long-term potentiation
sedation
Journal
Frontiers in systems neuroscience
ISSN: 1662-5137
Titre abrégé: Front Syst Neurosci
Pays: Switzerland
ID NLM: 101477946
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
01
2020
accepted:
21
04
2020
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
13
6
2020
Statut:
epublish
Résumé
Exposure to sedative/hypnotic and anesthetic drugs, such as ketamine, during the critical period of synaptogenesis, causes profound neurotoxicity in the developing rodent and primate brains and is associated with poor cognitive outcomes later in life. The subiculum is especially vulnerable to acute neurotoxicity after neonatal exposure to sedative/hypnotic and anesthetic drugs. The subiculum acts as a relay center between the hippocampal complex and various cortical and subcortical brain regions and is also an independent generator of gamma oscillations. Gamma oscillations are vital in neuronal synchronization and play a role in learning and memory during wake and sleep. However, there has been little research examining long-term changes in subicular neurophysiology after neonatal exposure to ketamine. Here we explore the lasting effects of neonatal ketamine exposure on sleep macrostructure as well as subicular neuronal oscillations and synaptic plasticity in rats. During the peak of rodent synaptogenesis at postnatal day 7, rat pups were exposed to either 40 mg/kg of ketamine over 12 h or to volume matched saline vehicle. At weaning age, a subset of rats were implanted with a cortical and subicular electroencephalogram electrode, and at postnatal day 31, we performed
Identifiants
pubmed: 32528257
doi: 10.3389/fnsys.2020.00026
pmc: PMC7264261
doi:
Types de publication
Journal Article
Langues
eng
Pagination
26Subventions
Organisme : NICHD NIH HHS
ID : R01 HD097990
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM102525
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS048154
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS086839
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118197
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS097586
Pays : United States
Informations de copyright
Copyright © 2020 Manzella, Joksimovic, Orfila, Fine, Dietz, Sampath, Fiedler, Tesic, Atluri, Raol, Jevtovic-Todorovic, Herson and Todorovic.
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