Seq-ing Higher Ground: Functional Investigation of Adaptive Variation Associated With High-Altitude Adaptation.
adaptive variation
functional investigation
genetic adaptation
genome editing
high-altitude adaptation
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
02
2020
accepted:
16
04
2020
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
13
6
2020
Statut:
epublish
Résumé
Human populations at high altitude exhibit both unique physiological responses and strong genetic signatures of selection thought to compensate for the decreased availability of oxygen in each breath of air. With the increased availability of genomic information from Tibetans, Andeans, and Ethiopians, much progress has been made to elucidate genetic adaptations to chronic hypoxia that have occurred throughout hundreds of generations in these populations. In this perspectives piece, we discuss specific hypoxia-pathway variants that have been identified in high-altitude populations and methods for functional investigation, which may be used to determine the underlying causal factors that afford adaptation to high altitude.
Identifiants
pubmed: 32528523
doi: 10.3389/fgene.2020.00471
pmc: PMC7247851
doi:
Types de publication
Journal Article
Langues
eng
Pagination
471Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL145470
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134632
Pays : United States
Informations de copyright
Copyright © 2020 Hall, Lawrence, Simonson and Fox.
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