A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-
CIAPs, cellular inhibitor of apoptosis proteins
Etan, etanercept
FADD, FAS-associated protein with death domain
FLIP
FLIP, cellular FLICE-inhibitory protein
IκB-α, NF-κB inhibitor alpha
LDH, lactate dehydrogenase
LPS
LPS, lipopolysaccharide
MLKL, mixed lineage kinase domain like pseudokinase
MPO, myeloperoxidase
NF-κB
PAS, periodic acid-schiff
RIPK1/3, receptor-interacting protein kinase 1/3
TNF-R1, tumor necrosis factor receptor type 1
TNF-α
TNFAIP3, TNF-α-induced protein 3
TP, triptolide
TRADD, TNF receptor-associated death domain
TRAF2, TNF receptor-associated factor 2
Triptolide
XIAP, X-linked inhibitor of apoptosis protein
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
24
05
2019
revised:
05
09
2019
accepted:
02
01
2020
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
13
6
2020
Statut:
ppublish
Résumé
Previously, we proposed a new perspective of triptolide (TP)-associated hepatotoxicity: liver hypersensitivity upon lipopolysaccharide (LPS) stimulation. However, the mechanisms for TP/LPS-induced hepatotoxicity remained elusive. The present study aimed to clarify the role of LPS in TP/LPS-induced hepatotoxicity and the mechanism by which TP induces liver hypersensitivity upon LPS stimulation. TNF-
Identifiants
pubmed: 32528833
doi: 10.1016/j.apsb.2020.02.009
pii: S2211-3835(19)30722-1
pmc: PMC7280150
doi:
Types de publication
Journal Article
Langues
eng
Pagination
861-877Informations de copyright
© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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