Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report.
Adverse event
Drug-induced lung injury
Leiomyosarcoma
Multityrosine kinase inhibitor
Organizing pneumoniae
Pazopanib
Journal
Respiratory medicine case reports
ISSN: 2213-0071
Titre abrégé: Respir Med Case Rep
Pays: England
ID NLM: 101604463
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
04
2020
revised:
26
05
2020
accepted:
28
05
2020
entrez:
13
6
2020
pubmed:
13
6
2020
medline:
13
6
2020
Statut:
epublish
Résumé
Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case.
Identifiants
pubmed: 32528844
doi: 10.1016/j.rmcr.2020.101112
pii: S2213-0071(20)30187-8
pii: 101112
pmc: PMC7276494
doi:
Types de publication
Case Reports
Langues
eng
Pagination
101112Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
None.
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