Sexual impairment in patients with hidradenitis suppurativa: a systematic review.
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
14
04
2020
accepted:
15
05
2020
pubmed:
13
6
2020
medline:
15
5
2021
entrez:
13
6
2020
Statut:
ppublish
Résumé
Hidradenitis suppurativa (HS) can cause considerable impact on several aspects of quality of life. Sexuality is a central aspect of quality of life. In recent years, there has been an increase in the number of articles on HS and sexuality. To achieve our aim of synthesizing the available scientific evidence on HS and sexual health, we conducted a systematic review in February 2020. The clinical databases used included Medline and Embase. All types of epidemiological articles were included; reviews, guidelines, protocols, conference abstracts and case report articles were excluded. Eleven studies were included for review, representing 42 729 patients with HS. The most common study design was cross-sectional with or without comparison group(s), conducted in an outpatient setting or through surveys. Prevalence of sexual dysfunction ranged between 51-62%, and in the case of erectile dysfunction, a specific kind of sexual dysfunction affecting penile erection, it ranged from between 52% and 60% of patients studied using validated questionnaires. Potential risk factors for sexual dysfunction among men and women were identified, mainly related to disease activity, symptoms and partners. Mood disorders like depression and anxiety appear to be associated with sexual dysfunction. Women were more affected by sexual distress. HS patients with sexual dysfunction had a decreased overall quality of life. With respect to treatment, surgery did not improve sexual function and there is no scientific evidence regarding medical treatments. Patients stated that they would like to treat their sexual problems with healthcare professionals. In conclusion, sexual and erectile dysfunction are common in HS patients, and negatively affect their quality of life. There are clinical factors potentially associated with this which should be identified and treated by dermatologists in the comprehensive care of HS patients. Prospective studies are needed to provide more scientific evidence on this unmet need.
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
345-352Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 European Academy of Dermatology and Venereology.
Références
Kurzen H, Kurokawa I, Jemec GB et al. What causes Hidradenitis suppurativa? Exp Dermatol 2008; 17: 455-456; discussion 457-472.
Molina-Leyva A, Cuenca-Barrales C. Pruritus and malodour in patients with Hidradenitis suppurativa: impact on quality of life and clinical features associated with symptom severity. Dermatology (Basel, Switzerland) 2020; 236: 59-65.
Revuz JE, Canoui-Poitrine F, Wolkenstein P et al. Prevalence and factors associated with Hidradenitis suppurativa: results from two case-control studies. J Am Acad Dermatol 2008; 59: 596-601.
Ingram JR, Jenkins-Jones S, Knipe DW, Morgan CLI, Cannings-John R, Piguet V. Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of Hidradenitis suppurativa. Br J Dermatol 2018; 178: 917-924.
Zouboulis CC, Desai N, Emtestam L et al. European S1 guideline for the treatment of Hidradenitis suppurativa/acne inversa. J Eur Acad Dermatol Venereol 2015; 29: 619-644.
Reddy S, Strunk A, Jemec GBE Garg A. Incidence of myocardial infarction and cerebrovascular accident in patients with Hidradenitis suppurativa. JAMA Dermatol 2019; 156: 1-7.
Rodriguez-Zuniga MJM, Garcia-Perdomo HA, Ortega-Loayza AG. Association between Hidradenitis suppurativa and metabolic syndrome: a systematic review and meta-analysis. Actas Dermo-sifiliograficas 2019; 110: 279-288.
Vilarrasa Rull E, Gonzalez Lama Y. Clinical features of Hidradenitis suppurativa and Crohn disease: what do these two entities have in common? Actas Dermo-sifiliograficas 2016; 107(Suppl 2): 21-26.
Balieva F, Kupfer J, Lien L et al. The burden of common skin diseases assessed with the EQ5D: a European multicentre study in 13 countries. Br J Dermatol 2017; 176: 1170-1178.
Onderdijk AJ, van der Zee HH, Esmann S et al. Depression in patients with Hidradenitis suppurativa. J Eur Acad Dermatol Venereol 2013; 27: 473-478.
Matusiak L, Bieniek A, Szepietowski JC. Psychophysical aspects of Hidradenitis suppurativa. Acta Dermato-venereologica 2010; 90: 264-268.
Kaaz K, Szepietowski JC, Matusiak L. Influence of itch and pain on sleep quality in patients with Hidradenitis suppurativa. Acta Dermato-venereologica 2018; 98: 757-761.
Kouris A, Platsidaki E, Christodoulou C et al. Quality of life and psychosocial implications in patients with Hidradenitis suppurativa. Dermatology (Basel, Switzerland) 2016; 232: 687-691.
Vangipuram R, Vaidya T, Jandarov R Alikhan A. Factors Contributing to depression and chronic pain in patients with Hidradenitis suppurativa: results from a single-center retrospective review. Dermatology (Basel, Switzerland) 2016; 232: 692-695.
Thorlacius L, Cohen AD, Gislason GH, Jemec GBE, Egeberg A. Increased suicide risk in patients with Hidradenitis suppurativa. J Invest Dermatol 2018; 138: 52-57.
Theut Riis P, Thorlacius L, Knudsen List E, Jemec GBE. A pilot study of unemployment in patients with Hidradenitis suppurativa in Denmark. Br J Dermatol 2017; 176: 1083-1085.
WHO Department of Reproductive Health and Research. Report of a technical consultation on sexual health. Geneva: WHO; 2006. URL http://www.who.int/reproductivehealth/publications/sexual_health/defining_sexual_health.pdf?ua=1 (updated 16/03/2014; accesed December 29, 2018).
Nappi RE, Cucinella L, Martella S, Rossi M, Tiranini L, Martini E. Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL). Maturitas 2016; 94: 87-91.
Nazarpour S, Simbar M, Ramezani Tehrani F, Alavi Majd H. Quality of life and sexual function in postmenopausal women. J Women Aging 2018; 30: 299-309.
Nusbaum MR, Hamilton C, Lenahan P. Chronic illness and sexual functioning. Am Family Phys 2003; 67: 347-354.
Yafi FA, Jenkins L, Albersen M et al. Erectile dysfunction. Nat Rev Disease Primers 2016; 2: 16003.
World Health Organization. International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). URL: https://icd.who.int/browse10/2016/en (last accessed September, 2019).
McCabe MP, Sharlip ID, Atalla E et al. Definitions of sexual dysfunctions in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015. J Sexual Med 2016; 13: 135-143.
OCEBM Levels of Evidence Working Group. “The Oxford Levels of Evidence 2”. Oxford Centre for Evidence-Based Medicine. https://www.cebm.net/index.aspx?o=5653
Kurek A, Peters EM, Chanwangpong A, Sabat R, Sterry W, Schneider-Burrus S. Profound disturbances of sexual health in patients with acne inversa. J Am Acad Dermatol 2012; 67: 422-428, e421.
Kurek A, Johanne Peters EM, Sabat R, Sterry W Schneider-Burrus S. Depression is a frequent co-morbidity in patients with acne inversa. J German Soc Dermatol 2013; 11: 743-749, 743-750.
Sampogna F, Abeni D, Gieler U et al. Impairment of sexual life in 3,485 dermatological outpatients from a multicentre study in 13 European countries. Acta Dermato-venereologica 2017; 97: 478-482.
Janse IC, Deckers IE, van der Maten AD et al. Sexual health and quality of life are impaired in Hidradenitis suppurativa: a multicentre cross-sectional study. Br J Dermatol 2017; 176: 1042-1047.
Alavi A, Farzanfar D, Rogalska T, Lowes MA, Chavoshi S. Quality of life and sexual health in patients with Hidradenitis suppurativa. Int J Women's Dermatol 2018; 4: 74-79.
Slyper M, Strunk A, Garg A. Incidence of sexual dysfunction among patients with Hidradenitis suppurativa: a population-based retrospective analysis. Br J Dermatol 2018; 179: 502-503.
Kluger N, Sintonen H, Ranta M, Serlachius M. Health-related quality of life of patients with Hidradenitis suppurativa measured with the 15D instrument and comparison with the general population and patients with psoriasis. Skin Appendage Disorders 2018; 4: 131-135.
Cuenca-Barrales C, Ruiz-Villaverde R, Molina-Leyva A. Sexual distress in patients with Hidradenitis suppurativa: a cross-sectional study. J Clin Med 2019; 8: 532.
Prens LM, Huizinga J, Janse IC, Horvath B. Surgical outcomes and the impact of major surgery on quality of life, activity impairment and sexual health in Hidradenitis suppurativa patients: a prospective single centre study. J Eur Acad Dermatol Venereol 2019; 33: 1941-1946.
Cuenca-Barrales C, Molina-Leyva A. Risk factors of sexual dysfunction in patients with Hidradenitis suppurativa: a cross-sectional study. Dermatology (Basel, Switzerland) 2020; 236: 37-45.
Garg A, Neuren E, Cha D et al. Evaluating patients' unmet needs in Hidradenitis suppurativa: Results from the Global Survey Of Impact and Healthcare Needs (VOICE) Project. J Am Acad Dermatol 2020; 82: 366-376.
Perez-Lopez FR, Fernandez-Alonso AM, Trabalon-Pastor M, Vara C, Chedraui P. Assessment of sexual function and related factors in mid-aged sexually active Spanish women with the six-item Female Sex Function Index. Menopause (New York, NY) 2012; 19: 1224-1230.
Chew KK, Stuckey B, Bremner A, Earle C, Jamrozik K. Male erectile dysfunction: its prevalence in Western australia and associated sociodemographic factors. J Sexual Med 2008; 5: 60-69.
Sanchez SC, Chedraui P, Perez-Lopez FR, Ortiz-Benegas ME, Palacios-De Franco Y. Evaluation of sexuality in a Paraguayan mid-aged female urban population using the six-item Female Sexual Function Index. Climacteric 2016; 19: 256-260.
Molina-Leyva A, Salvador-Rodriguez L, Martinez-Lopez A, Ruiz-Carrascosa JC, Arias-Santiago S. Association between psoriasis and sexual and erectile dysfunction in epidemiologic studies: a systematic review. JAMA Dermatol 2019; 155: 98-106.
Rhoden EL, Teloken C, Sogari PR, Vargas Souto CA. The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. Int J Impotence Res 2002; 14: 245-250.
Alavi A, Farzanfar D, Lee RK, Almutairi D. The contribution of malodour in quality of life of patients with Hidradenitis suppurativa. J Cutaneous Med Surg 2018; 22: 166-174.
McCabe MP, Sharlip ID, Lewis R et al. Risk factors for sexual dysfunction among women and men: a consensus statement from the fourth international consultation on sexual medicine 2015. J Sexual Med 2016; 13: 153-167.
El-Sakka AI. Dehydroepiandrosterone and erectile function: a review. World J Men's Health 2018; 36: 183-191.
Schneider-Burrus S, Jost A, Peters EMJ, Witte-Haendel E, Sterry W, Sabat R. Association of Hidradenitis suppurativa with body image. JAMA Dermatol 2018; 154: 447-451.
Wlodarek K, Glowaczewska A, Matusiak L, Szepietowski JC. Psychosocial burden of Hidradenitis suppurativa patients' partners. J Eur Acad Dermatol Venereol 2020; 34: 1822-1827.
Meeuwis KA, de Hullu JA, van de Nieuwenhof HP et al. Quality of life and sexual health in patients with genital psoriasis. Br J Dermatol 2011; 164: 1247-1255.
Reese JB, Handorf E, Haythornthwaite JA. Sexual quality of life, body image distress, and psychosocial outcomes in colorectal cancer: a longitudinal study. Supportive Care Cancer 2018; 26: 3431-3440.
Kroenke K, Spitzer RL. Gender differences in the reporting of physical and somatoform symptoms. Psychosomatic Med 1998; 60: 150-155.
Gupta MA, Gupta AK. Psoriasis and sex: a study of moderately to severely affected patients. Int J Dermatol 1997; 36: 259-262.
Molina-Leyva A, Jimenez-Moleon JJ, Naranjo-Sintes R, Ruiz-Carrascosa JC. Sexual dysfunction in psoriasis: a systematic review. J Eur Acad Dermatol Venereol 2015; 29: 649-655.