Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice.

Animals Depression / drug therapy Hippocampus KATP Channels Memantine / pharmacology Mice Olfactory Bulb
Kir6.1 channel inhibition depressive-like behaviors memantine neurogenesis olfactory bulbectomized mice

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
21 08 2020
Historique:
received: 28 01 2020
revised: 29 05 2020
accepted: 02 06 2020
pubmed: 13 6 2020
medline: 15 5 2021
entrez: 13 6 2020
Statut: ppublish

Résumé

Aberrant depressive-like behaviors in olfactory bulbectomized (OBX) mice have been documented by previous studies. Here, we show that memantine enhances adult neurogenesis in the subgranular zone of the hippocampal dentate gyrus (DG) and improves depressive-like behaviors via inhibition of the ATP-sensitive potassium (K

Identifiants

DOI: 10.1016/j.neuroscience.2020.06.002 PMID: 32531473
pubmed: 32531473
pii: S0306-4522(20)30371-7
doi: 10.1016/j.neuroscience.2020.06.002
pii:
doi:

Substances chimiques

KATP Channels 0
uK-ATP-1 potassium channel 0
Memantine W8O17SJF3T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

264-273

Informations de copyright

Copyright © 2020 IBRO. All rights reserved.

Auteurs

Shigeki Moriguchi (S)

Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. Electronic address: shigeki.moriguchi.a3@tohoku.ac.jp.

Ryo Inagaki (R)

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Hirotsugu Shimojo (H)

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Yoshihiko Sugimura (Y)

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Kohji Fukunaga (K)

Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Memantine Improves Depressive-like Behaviors...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Memantine Improves Depressive-like Behaviors...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Memantine Improves Depressive-like Behaviors...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques rectifiants entrants › Canaux KATP › Memantine Improves Depressive-like Behaviors...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Amantadine › Mémantine › Memantine Improves Depressive-like Behaviors...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Memantine Improves Depressive-like Behaviors...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Bulbe olfactif › Memantine Improves Depressive-like Behaviors...