State-of-the-Art Technology of Model Organisms for Current Human Medicine.
biology
diagnosis
regenerative medicine
therapy
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
10 Jun 2020
10 Jun 2020
Historique:
received:
17
04
2020
revised:
27
05
2020
accepted:
09
06
2020
entrez:
14
6
2020
pubmed:
14
6
2020
medline:
14
6
2020
Statut:
epublish
Résumé
Since the 1980s, molecular biology has been used to investigate medical field mechanisms that still require the use of crude biological materials in order to achieve their necessary goals. Transcription factor-induced pluripotent stem cells are used in regenerative medicine to screen drugs and to support lost tissues. However, these cells insufficiently reconstruct whole organs and require various intact cells, such as damaged livers and diabetic pancreases. For efficient gene transfer in medical use, virally mediated gene transfers are used, although immunogenic issues are investigated. To obtain efficient detective and diagnostic power in intractable diseases, biological tools such as roundworms and zebrafish have been found to be useful for high-throughput screening (HST) and diagnosis. Taken together, this biological approach will help to fill the gaps between medical needs and novel innovations in the field of medicine.
Identifiants
pubmed: 32532032
pii: diagnostics10060392
doi: 10.3390/diagnostics10060392
pmc: PMC7345323
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 15H05791; 17H04282; 17K19698; 18K16356; 18K16355
Organisme : Japan Agency for Medical Research and Development
ID : 16cm0106414h0001; 17cm0106414h0002
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