Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency.
HBV small surface antigen (sHBsAg)
hepatitis C virus
vaccine
virus like particles (VLPs)
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
10 Jun 2020
10 Jun 2020
Historique:
received:
23
04
2020
revised:
30
05
2020
accepted:
06
06
2020
entrez:
14
6
2020
pubmed:
14
6
2020
medline:
14
6
2020
Statut:
epublish
Résumé
Hepatitis C virus (HCV) infection with associated chronic liver diseases is a major health problem worldwide. Here, we designed hepatitis B virus (HBV) small surface antigen (sHBsAg) virus-like particles (VLPs) presenting different epitopes derived from the HCV E2 glycoprotein (residues 412-425, 434-446, 502-520, and 523-535 of isolate H77C). Epitopes were selected based on their amino acid sequence conservation and were previously reported as targets of HCV neutralizing antibodies. Chimeric VLPs obtained in the
Identifiants
pubmed: 32532076
pii: vaccines8020294
doi: 10.3390/vaccines8020294
pmc: PMC7350033
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Narodowe Centrum Nauki
ID : UMO-2016/23/N/NZ6/02503
Organisme : Narodowe Centrum Nauki
ID : UMO-2017/27/B/NZ6/01403
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