Modeling intracranial aneurysm stability and growth: an integrative mechanobiological framework for clinical cases.
Fluid–solid-growth
Growth
Intracranial aneurysm
Remodelling
Journal
Biomechanics and modeling in mechanobiology
ISSN: 1617-7940
Titre abrégé: Biomech Model Mechanobiol
Pays: Germany
ID NLM: 101135325
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
13
08
2019
accepted:
12
05
2020
pubmed:
14
6
2020
medline:
24
8
2021
entrez:
14
6
2020
Statut:
ppublish
Résumé
We present a novel patient-specific fluid-solid-growth framework to model the mechanobiological state of clinically detected intracranial aneurysms (IAs) and their evolution. The artery and IA sac are modeled as thick-walled, non-linear elastic fiber-reinforced composites. We represent the undulation distribution of collagen fibers: the adventitia of the healthy artery is modeled as a protective sheath whereas the aneurysm sac is modeled to bear load within physiological range of pressures. Initially, we assume the detected IA is stable and then consider two flow-related mechanisms to drive enlargement: (1) low wall shear stress; (2) dysfunctional endothelium which is associated with regions of high oscillatory flow. Localized collagen degradation and remodelling gives rise to formation of secondary blebs on the aneurysm dome. Restabilization of blebs is achieved by remodelling of the homeostatic collagen fiber stretch distribution. This integrative mechanobiological modelling workflow provides a step towards a personalized risk-assessment and treatment of clinically detected IAs.
Identifiants
pubmed: 32533497
doi: 10.1007/s10237-020-01351-2
pii: 10.1007/s10237-020-01351-2
pmc: PMC7603456
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2413-2431Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 2014/261
Organisme : Engineering and Physical Sciences Research Council
ID : EP/N014642/1
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