Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.
Animals
Antioxidants
/ physiology
Cell Proliferation
/ physiology
Cells, Cultured
Cellular Senescence
/ genetics
Endoplasmic Reticulum Stress
/ physiology
Fibroblasts
Gene Expression
/ genetics
Gene Expression Regulation
/ genetics
Mice
Nicotinamide Phosphoribosyltransferase
/ genetics
Oxidation-Reduction
Oxidative Stress
/ physiology
ER stress
NAD+
NAMPT
oxidative stress
premature senescence
Journal
Genes to cells : devoted to molecular & cellular mechanisms
ISSN: 1365-2443
Titre abrégé: Genes Cells
Pays: England
ID NLM: 9607379
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
01
05
2020
revised:
31
05
2020
accepted:
01
06
2020
pubmed:
14
6
2020
medline:
1
7
2021
entrez:
14
6
2020
Statut:
ppublish
Résumé
A main feature of aged organisms is the accumulation of senescent cells. Accumulated senescent cells, especially stress-induced premature senescent cells, in aged organisms lead to the decline of the regenerative potential and function of tissues. We recently reported that the over-expression of NAMPT, which is the rate-limiting enzyme in mammalian NAD
Substances chimiques
Antioxidants
0
Nicotinamide Phosphoribosyltransferase
EC 2.4.2.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
593-602Subventions
Organisme : Takeda Science Foundation
Organisme : Japan Society for the Promotion of Science
ID : KAKENHI Grant Number 17K08569
Informations de copyright
© 2020 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.
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