Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II.
Animals
Biocatalysis
/ drug effects
Cell Death
/ drug effects
Cell Line
Cell Proliferation
/ drug effects
Coordination Complexes
/ chemical synthesis
DNA Topoisomerases, Type I
/ metabolism
DNA Topoisomerases, Type II
/ metabolism
Humans
Mice
Molecular Structure
Necroptosis
/ drug effects
Neoplasms, Experimental
/ drug therapy
Poly-ADP-Ribose Binding Proteins
/ antagonists & inhibitors
Ruthenium
/ chemistry
Topoisomerase Inhibitors
/ chemical synthesis
bioinorganic chemistry
medicinal inorganic chemistry
metals in medicine
necroptosis
ruthenium
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
14 09 2020
14 09 2020
Historique:
received:
27
04
2020
revised:
10
06
2020
pubmed:
14
6
2020
medline:
19
3
2021
entrez:
14
6
2020
Statut:
ppublish
Résumé
Inducing necroptosis in cancer cells is an effective approach to circumvent drug-resistance. Metal-based triggers have, however, rarely been reported. Ruthenium(II) complexes containing 1,1-(pyrazin-2-yl)pyreno[4,5-e][1,2,4]triazine were developed with a series of different ancillary ligands (Ru1-7). The combination of the main ligand with bipyridyl and phenylpyridyl ligands endows Ru7 with superior nucleus-targeting properties. As a rare dual catalytic inhibitor, Ru7 effectively inhibits the endogenous activities of topoisomerase (topo) I and II and kills cancer cells by necroptosis. The cell signaling pathway from topo inhibition to necroptosis was elucidated. Furthermore, Ru7 displays significant antitumor activity against drug-resistant cancer cells in vivo. To the best of our knowledge, Ru7 is the first Ru-based necroptosis-inducing chemotherapeutic agent.
Identifiants
pubmed: 32533618
doi: 10.1002/anie.202006089
doi:
Substances chimiques
Coordination Complexes
0
Poly-ADP-Ribose Binding Proteins
0
Topoisomerase Inhibitors
0
Ruthenium
7UI0TKC3U5
DNA Topoisomerases, Type I
EC 5.99.1.2
TOP1 protein, human
EC 5.99.1.2
DNA Topoisomerases, Type II
EC 5.99.1.3
TOP2A protein, human
EC 5.99.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16631-16637Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Deposition Numbers 1941708 (for Ru1), 1941709 (for Ru2), 1941706 (for Ru3), 1941707 (for Ru5), and 1941705 (for Ru6) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service www.ccdc.cam.ac.uk/structures.