First Detection of SARS-CoV-2 by Real-Time Reverse Transcriptase-Polymerase Chain Reaction Assay in Pleural Fluid.
Aged
Betacoronavirus
/ isolation & purification
COVID-19
COVID-19 Testing
COVID-19 Vaccines
Clinical Laboratory Techniques
Coronavirus Infections
/ complications
Humans
Male
Pandemics
Pleural Effusion
/ virology
Pneumonia, Viral
/ complications
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
CT-guided biopsy
diagnostic yield
meta-analysis
pleural lesions
safety
ultrasound-guided biopsy
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
21
04
2020
revised:
19
05
2020
accepted:
29
05
2020
pubmed:
15
6
2020
medline:
22
10
2020
entrez:
15
6
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) is a pandemic infection due to the spread of a novel coronavirus (severe acute respiratory syndrome coronavirus 2), resulting in a wide range of clinical features, from asymptomatic carriers to ARDS. The gold standard for diagnosis is nucleic acid detection by real-time reverse transcriptase-polymerase chain reaction in nasopharyngeal swabs. However, due to limitations in this technique's sensitivity, thoracic imaging plays a crucial, complementary role in diagnostic evaluation and also allows for detection of atypical findings and potential alternative targets for sampling (eg, pleural effusion). Although less common, pleural involvement has been described in a minority of patients. This report describes the first case of reverse transcriptase-polymerase chain reaction detection of severe acute respiratory syndrome coronavirus 2 in pleural fluid obtained by means of ultrasound-guided thoracentesis, and its main characteristics are detailed. Pleural effusion is not a common finding in COVID-19 infection, but a prompt recognition of this potential localization may be useful to optimize diagnostic evaluation as well as the management of these patients.
Identifiants
pubmed: 32534909
pii: S0012-3692(20)31660-3
doi: 10.1016/j.chest.2020.05.583
pmc: PMC7287448
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e143-e146Informations de copyright
Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
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