Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy.
Age Factors
Aged
Betacoronavirus
/ immunology
COVID-19
Comorbidity
Coronary Disease
/ diagnosis
Coronavirus Infections
/ diagnosis
Diabetes Mellitus
/ diagnosis
Female
Hospitalization
Humans
Hypertension
/ diagnosis
Infectious Disease Incubation Period
Italy
/ epidemiology
Kidney Failure, Chronic
/ diagnosis
Lymphocyte Count
Lymphocytes
/ immunology
Male
Middle Aged
Pandemics
Pneumonia, Viral
/ diagnosis
Pulmonary Edema
/ diagnosis
Risk Factors
SARS-CoV-2
Severe Acute Respiratory Syndrome
/ diagnosis
Severity of Illness Index
Survival Analysis
ARDS
COVID-19
Infection
RALE score
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
25
05
2020
revised:
07
06
2020
accepted:
10
06
2020
pubmed:
15
6
2020
medline:
22
7
2020
entrez:
15
6
2020
Statut:
ppublish
Résumé
National health-system hospitals of Lombardy faced a heavy burden of admissions for acute respiratory distress syndromes associated with coronavirus disease (COVID-19). Data on patients of European origin affected by COVID-19 are limited. All consecutive patients aged ≥18 years, coming from North-East of Milan's province and admitted at San Raffaele Hospital with COVID-19, between February 25th and March 24th, were reported, all patients were followed for at least one month. Clinical and radiological features at admission and predictors of clinical outcomes were evaluated. Of the 500 patients admitted to the Emergency Unit, 410 patients were hospitalized and analyzed: median age was 65 (IQR 56-75) years, and the majority of patients were males (72.9%). Median (IQR) days from COVID-19 symptoms onset was 8 (5-11) days. At hospital admission, fever (≥ 37.5 °C) was present in 67.5% of patients. Median oxygen saturation (SpO2) was 93% (range 60-99), with median PaO In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE.
Sections du résumé
BACKGROUND
National health-system hospitals of Lombardy faced a heavy burden of admissions for acute respiratory distress syndromes associated with coronavirus disease (COVID-19). Data on patients of European origin affected by COVID-19 are limited.
METHODS
All consecutive patients aged ≥18 years, coming from North-East of Milan's province and admitted at San Raffaele Hospital with COVID-19, between February 25th and March 24th, were reported, all patients were followed for at least one month. Clinical and radiological features at admission and predictors of clinical outcomes were evaluated.
RESULTS
Of the 500 patients admitted to the Emergency Unit, 410 patients were hospitalized and analyzed: median age was 65 (IQR 56-75) years, and the majority of patients were males (72.9%). Median (IQR) days from COVID-19 symptoms onset was 8 (5-11) days. At hospital admission, fever (≥ 37.5 °C) was present in 67.5% of patients. Median oxygen saturation (SpO2) was 93% (range 60-99), with median PaO
CONCLUSION
In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE.
Identifiants
pubmed: 32535188
pii: S1521-6616(20)30456-3
doi: 10.1016/j.clim.2020.108509
pmc: PMC7289745
pii:
doi:
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108509Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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