Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants.
CD36
adipocytokines
miR-146a
miR-21
obesity
Journal
Archives of physiology and biochemistry
ISSN: 1744-4160
Titre abrégé: Arch Physiol Biochem
Pays: England
ID NLM: 9510153
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
pubmed:
17
6
2020
medline:
25
10
2022
entrez:
16
6
2020
Statut:
ppublish
Résumé
The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants. Our study included male obese, without co-morbidities ( miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-α, and CD36 in obese participants. We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants.
Sections du résumé
BACKGROUND
UNASSIGNED
The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants.
METHODS
UNASSIGNED
Our study included male obese, without co-morbidities (
RESULTS
UNASSIGNED
miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-α, and CD36 in obese participants.
CONCLUSION
UNASSIGNED
We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants.
Identifiants
pubmed: 32536220
doi: 10.1080/13813455.2020.1775655
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Interleukin-6
0
MicroRNAs
0
MIRN21 microRNA, human
0
Tumor Necrosis Factor-alpha
0
MIRN146 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM