A Patient with Necrotizing Vasculitis Related to Sarcoidosis, which Was Diagnosed via Immunohistochemical Methods Using Propionibacterium acnes-specific Monoclonal Antibodies.
Anti-Bacterial Agents
/ therapeutic use
Antibodies, Monoclonal
/ administration & dosage
Biopsy
/ methods
Female
Granuloma
/ diagnosis
Humans
Immunohistochemistry
/ methods
Japan
Middle Aged
Minocycline
/ therapeutic use
Propionibacterium acnes
Sarcoidosis
/ complications
Treatment Outcome
Vasculitis
/ diagnosis
P. acnes
necrotizing vasculitis
sarcoidosis
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
pubmed:
17
6
2020
medline:
20
1
2021
entrez:
16
6
2020
Statut:
ppublish
Résumé
Propionibacterium acnes (P. acnes) is a commensal bacterium indigenous to the skin. Previous reports have suggested that infection with P. acnes causes sarcoidosis, a systemic granulomatous disease. We present the case of a 63-year-old woman who developed subcutaneous nodules. A skin biopsy revealed necrotizing vasculitis and noncaseating granulomas, which are characteristic of sarcoidosis. Immunohistostaining revealed a P. acnes skin infection, which led to the diagnosis of sarcoidosis. Minocycline treatment resolved the infection and improved the patient's symptoms. We herein report a case in which immunohistochemistry was useful in the diagnosis of sarcoidosis.
Identifiants
pubmed: 32536653
doi: 10.2169/internalmedicine.4918-20
pmc: PMC7644481
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antibodies, Monoclonal
0
Minocycline
FYY3R43WGO
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2423-2425Références
Clin Exp Immunol. 1995 Dec;102(3):635-41
pubmed: 8536384
Mod Pathol. 2012 Sep;25(9):1284-97
pubmed: 22596102
Lancet. 1999 Jul 10;354(9173):120-3
pubmed: 10408488
Intern Med. 2019 May 15;58(10):1473-1477
pubmed: 30626837
J Clin Microbiol. 2002 Jan;40(1):198-204
pubmed: 11773116
J Eur Acad Dermatol Venereol. 2015 Nov;29(11):2104-11
pubmed: 26419478
JAMA Dermatol. 2013 Jun;149(6):758-60
pubmed: 23783160
J Clin Rheumatol. 2018 Dec 5;:
pubmed: 30586000
BMC Pulm Med. 2016 Feb 11;16:30
pubmed: 26864464
Magn Reson Med Sci. 2012;11(2):83-9
pubmed: 22790294
Dis Mon. 2009 Nov;55(11):649-60
pubmed: 19857640
Sarcoidosis Vasc Diffuse Lung Dis. 2008 Sep;25(1):15-20
pubmed: 19070256
Drugs. 2008;68(10):1361-83
pubmed: 18578557
Int J Dermatol. 2015 Jan;54(1):1-12
pubmed: 25312788
Respir Investig. 2013 Jun;51(2):56-68
pubmed: 23790733