Solubility Determination and Correlation of Warfarin Sodium 2‑Propanol Solvate in Pure, Binary, and Ternary Solvent Mixtures.
Journal
Journal of chemical and engineering data
ISSN: 0021-9568
Titre abrégé: J Chem Eng Data
Pays: United States
ID NLM: 17840090R
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
entrez:
16
6
2020
pubmed:
11
4
2019
medline:
11
4
2019
Statut:
ppublish
Résumé
The solubility of warfarin sodium isopropanol solvate (WS·IPA), a widely used anticoagulant, was determined at temperatures ranging from 278.15 to 333.15 K in four pure solvents (acetone, ethanol, IPA, and water), five binary solvent mixtures (IPA + acetone, IPA + ethanol, IPA + water, IPA + heptane, and IPA + hexane), and five ternary solvent mixtures (IPA + acetone + heptane, IPA + acetone + hexane, IPA + ethanol + heptane, IPA + ethanol + hexane, and IPA + water + heptane) using the polythermal method. It was demonstrated that the solubility of WS·IPA increases with increasing temperature in the pure solvents and at constant solvent composition in the solvent mixtures. In addition, the solubility of WS·IPA in IPA increases with increasing content of acetone, ethanol, and water, which act as cosolvents, and decreases with increasing content of heptane and hexane, which act as antisolvents. The experimental solubility data of WS·IPA in pure solvents and binary and ternary solvent mixtures were correlated using the modified Apelblat and
Identifiants
pubmed: 32536719
doi: 10.1021/acs.jced.8b00977
pmc: PMC7291792
mid: NIHMS1023593
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1399-1413Subventions
Organisme : NIMHD NIH HHS
ID : G12 MD007600
Pays : United States
Déclaration de conflit d'intérêts
Notes The authors declare no competing financial interest.
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