Physical Exercise May Increase Plasma Concentration of High-Density Lipoprotein-Cholesterol in Patients With Alzheimer's Disease.
Alzheimer’s disease
HDL-C
cholesterol
exercise
fitness
lipid profile
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
01
2020
accepted:
29
04
2020
entrez:
16
6
2020
pubmed:
17
6
2020
medline:
17
6
2020
Statut:
epublish
Résumé
Lifestyle factors have been shown to increase the risk of developing Alzheimer's disease (AD) later in life. Specifically, an unfavorable cholesterol profile, and insulin resistance are associated with increased risk of developing AD. One way to non-pharmacologically affect the levels of plasma lipids is by exercise, which has been shown to be beneficial in cognitively healthy individuals. In this randomized controlled trial y, we therefore aimed to clarify the effect of physical exercise on the lipid profile, insulin and glucose in patients with AD. In addition, we investigated the effect of apolipoproteinE genotype on total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglycerides (TG) in plasma from patients with AD. Plasma samples from 172 patients who underwent 16 weeks of moderate-to-high intensity exercise (
Identifiants
pubmed: 32536853
doi: 10.3389/fnins.2020.00532
pmc: PMC7269030
doi:
Types de publication
Journal Article
Langues
eng
Pagination
532Informations de copyright
Copyright © 2020 Jensen, Musaeus, Frikke-Schmidt, Andersen, Beyer, Gottrup, Høgh, Vestergaard, Wermuth, Frederiksen, Waldemar, Hasselbalch and Simonsen.
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