Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel
MRI
SPAST gene mutation
SPG4-hereditary spastic paraplegia
brain
gray-matter changes
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
10
2019
accepted:
17
04
2020
entrez:
16
6
2020
pubmed:
17
6
2020
medline:
17
6
2020
Statut:
epublish
Résumé
To determine the cortical mechanism that underlies the cognitive impairment and motor disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family were examined using clinical evaluation, cognitive screening, and genetic testing. Controls were matched healthy subjects. White-matter fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD; tract-based spatial statistics), cortical thickness (FreeSurfer), and subcortical gray matter (FIRST) based on T1-weighted MRI and diffusion tensor imaging were analyzed. A novel mutation in the
Identifiants
pubmed: 32536902
doi: 10.3389/fneur.2020.00399
pmc: PMC7267220
doi:
Types de publication
Journal Article
Langues
eng
Pagination
399Informations de copyright
Copyright © 2020 Lin, Zheng, Ma, Wang, Fan, Wu, Wang, Zhang and Zhan.
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