Evidence of jaagsiekte sheep retrovirus-induced pulmonary adenocarcinoma in Ouled Djellal breed sheep in Algeria.
Algeria
Immunohistochemistry
Pulmonary adenocarcinoma
Retrovirus
Sheep
Journal
Veterinary research forum : an international quarterly journal
ISSN: 2008-8140
Titre abrégé: Vet Res Forum
Pays: Iran
ID NLM: 101625812
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
16
6
2020
pubmed:
17
6
2020
medline:
17
6
2020
Statut:
ppublish
Résumé
We report the occurrence of lung cancer in a six months old lamb of Ouled Djellal breed from Algeria. The main clinical sign was a considerable amount of whitish foamy fluid discharge from the nostrils when the animal head was lowered and the rear end was lifted. The post-mortem examination revealed the presence of enlarged, heavy and edematous lungs with diffuse or foci areas, reddish or white-gray in color. The gross and histological lesions of the lungs were compatible with pulmonary adenocarcinoma. Lung adenocarcinoma in sheep is caused by jaagsiekte sheep retrovirus (JSRV) and originated from differentiated alveolar type II cells and non-ciliated bronchiolar epithelial Clara cells. We evidenced the expression of the oncogenic JSRV by immunostaining of lung slides with specific antibodies against the JSRV envelope. The viral proteins were expressed only in the tumor cells from the affected areas. As already described in other countries, JSRV-induced lung adenocarcinoma is present in the sheep population in Algeria.
Identifiants
pubmed: 32537113
doi: 10.30466/vrf.2019.107160.2549
pmc: PMC7282212
doi:
Types de publication
Case Reports
Langues
eng
Pagination
93-95Informations de copyright
© 2020 Urmia University. All rights reserved.
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