Se Deficiency Induced Inflammation Resulting to a Diminished Contraction of the Small Intestinal Smooth Muscle in Mice.
Contraction
Inflammation
Pathways
Selenium
Small intestinal smooth muscle
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
06
05
2020
accepted:
08
06
2020
pubmed:
17
6
2020
medline:
22
6
2021
entrez:
16
6
2020
Statut:
ppublish
Résumé
Selenium (Se) is an essential trace element for both humans and animals. Se deficiency leads to myocardial injury, reproductive disorder, increased exudation, inflammatory injury, and other diseases. The present study analyzed the relationships of Se deficiency, inflammation, and smooth muscle contraction in the small intestine, which is the main tissue that digests and absorbs Se. The model was established by feeding the animals diets with different concentrations of Se. The results showed that the dietary Se content was positively correlated with the blood Se concentration and the intestinal Se concentration. ROS and MPO activity increased with the lack of Se. TNF-α, IL-1β, and IL-6 expression was increased at both the mRNA and protein levels with Se deficiency. The pathways tested showed that the IκBα, NF-κB p65, p38, ERK, and JNK phosphorylation levels were significantly increased with the lack of Se. Moreover, the contractility analysis confirmed that contraction of the intestinal smooth muscle was attenuated by Se deficiency, as shown by the MedLab data acquisition system. These results further illuminated the relationship between inflammation and inhibition of smooth muscle contraction under Se deficiency in the small intestine. The Ca
Identifiants
pubmed: 32537720
doi: 10.1007/s12011-020-02245-1
pii: 10.1007/s12011-020-02245-1
doi:
Substances chimiques
NF-kappa B
0
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1437-1444Subventions
Organisme : National Natural Science Foundation of China
ID : 31602066
Organisme : Heilongjiang PostDoctoral Financial Assistance
ID : LBH-Z16017
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