Losartan potassium sustained release pellets with improved
Acrylic Resins
/ chemistry
Animals
Cellulose
/ chemistry
Chemistry, Pharmaceutical
/ methods
Delayed-Action Preparations
/ chemistry
Drug Implants
/ chemistry
Hydrophobic and Hydrophilic Interactions
Losartan
/ chemistry
Male
Molecular Weight
Polyethylene Glycols
/ chemistry
Polymers
/ chemistry
Rabbits
Solubility
/ drug effects
Tablets
/ chemistry
Losartan potassium
extrusion/spheronization
matrix pellet
pharmacokinetics
sustained release
Journal
Pharmaceutical development and technology
ISSN: 1097-9867
Titre abrégé: Pharm Dev Technol
Pays: England
ID NLM: 9610932
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
pubmed:
17
6
2020
medline:
8
7
2021
entrez:
16
6
2020
Statut:
ppublish
Résumé
The aim of this study was to formulate and evaluate SR matrix pellets containing losartan potassium (LP) solid dispersion using extrusion-spheronization technique to minimize the fluctuation of its plasma concentration. LP solid dispersions were prepared by using different hydrophobic polymers at different weight ratios (0.5, 1, 2, and 5%). LP-Eudragit RS solid dispersion at 1:5 ratio resulted in slower drug release (only 20% of LP was released in about 8 h). Different concentrations of hydrophilic polymer, PEG 6000, were mixed with Avicel
Identifiants
pubmed: 32538215
doi: 10.1080/10837450.2020.1782934
doi:
Substances chimiques
Acrylic Resins
0
Delayed-Action Preparations
0
Drug Implants
0
Polymers
0
Tablets
0
Polyethylene Glycol 6000
30IQX730WE
Eudragit RS
33434-24-1
Polyethylene Glycols
3WJQ0SDW1A
Cellulose
9004-34-6
Losartan
JMS50MPO89
microcrystalline cellulose
OP1R32D61U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM