Secukinumab retreatment associated psoriasis flare with pustules.


Journal

The Journal of dermatological treatment
ISSN: 1471-1753
Titre abrégé: J Dermatolog Treat
Pays: England
ID NLM: 8918133

Informations de publication

Date de publication:
Mar 2022
Historique:
pubmed: 17 6 2020
medline: 8 4 2022
entrez: 16 6 2020
Statut: ppublish

Résumé

This case report describes a patient with plaque psoriasis and psoriatic arthritis who experienced IL-17A blocking antibody secukinumab treatment-interruption followed by re-treatment. The patient showed heterogeneous responses; significant improvement at initial introduction of secukinumab with rapid deterioration after discontinuation, followed by worsening symptoms and pustular eruption with reintroduction, and skin clearance after dose escalation.

Identifiants

pubmed: 32538223
doi: 10.1080/09546634.2020.1782816
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
secukinumab DLG4EML025

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1107-1110

Auteurs

Mohamed El-Komy (M)

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Marwa Amer (M)

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Alshimaa Mostafa (A)

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Dermatology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Mona ElKalioby (M)

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

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Classifications MeSH