Pathogens Shape Sex Differences in Mammalian Aging.
immunosenescence
life-history traits
lifespan
medicine
pathogen exposure
Journal
Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
17
03
2020
revised:
01
05
2020
accepted:
01
05
2020
pubmed:
17
6
2020
medline:
28
11
2020
entrez:
17
6
2020
Statut:
ppublish
Résumé
Understanding the origin of sex differences in lifespan and aging patterns remains a salient challenge in both biogerontology and evolutionary biology. Different factors have been studied but the potential influence of pathogens has never been investigated. Sex differences, especially in hormones and resource allocation, generate a differential response to pathogens and thereby shape sex differences in lifespan or aging. We provide an integrative framework linking host pathogenic environment with both sex-specific selections on immune performance and mortality trajectories. We propose future directions to fill existing knowledge gaps about mechanisms that link sex differences, not only to exposition and sensitivity to pathogens, but also to mortality patterns, whilst emphasizing the urgent need to consider the role of sex in medicine.
Identifiants
pubmed: 32540194
pii: S1471-4922(20)30132-X
doi: 10.1016/j.pt.2020.05.004
pmc: PMC7203054
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
668-676Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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