Inhibition of Itch by Hunger and AgRP Neuron Activity.
AgRP
competing needs
hunger
hypothalamus
itch
somatosensory
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
19
02
2020
revised:
12
05
2020
accepted:
02
06
2020
pubmed:
17
6
2020
medline:
15
5
2021
entrez:
17
6
2020
Statut:
ppublish
Résumé
Unpleasant somatosensory stimuli such as pain and itch can interrupt normal behavior. But survival can depend on resuming normal behavior before these challenges are fully resolved. The neural mechanisms that prioritize behavior when individuals are challenged with unpleasant somatosensory sensations, however, are not fully understood. Recently, we identified a neural circuit activated by hunger that can inhibit pain, prioritizing food seeking over tending to an injury. Here, we examine the ability of hunger, and neurons activated by hunger, to inhibit behavioral responses to another unpleasant somatosensory sensation - itch. We demonstrate that food deprivation inhibits scratching induced by three different pruritogenic stimuli: histamine, serotonin, and chloroquine. The inhibition of scratching correlates with the level of food deprivation, suggesting a cross-competition of alarm systems in the brain whereby more energy need more efficiently inhibits competing drives. Finally, we show that activity in hunger-sensitive, hypothalamic agouti-related protein (AgRP)-expressing neurons is sufficient to inhibit itch. Taken together, we showed that hunger or AgRP neuron activity inhibits itch, demonstrating that organisms have neural systems to filter and process ascending spinal signals activated by unpleasant somatosensory stimuli to prioritize salient needs.
Identifiants
pubmed: 32540365
pii: S0306-4522(20)30372-9
doi: 10.1016/j.neuroscience.2020.06.005
pmc: PMC7688492
mid: NIHMS1603799
pii:
doi:
Substances chimiques
Agouti-Related Protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
126-134Subventions
Organisme : NIDDK NIH HHS
ID : K99 DK119574
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK119574
Pays : United States
Informations de copyright
Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
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