Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging.

Adaptive Immunity Animals Humans Magnetic Resonance Imaging / instrumentation Mice Neoplasms / diagnostic imaging Reactive Oxygen Species / immunology

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
15 06 2020
Historique:
received: 19 09 2019
accepted: 14 05 2020
entrez: 17 6 2020
pubmed: 17 6 2020
medline: 28 8 2020
Statut: epublish

Résumé

Tumor heterogeneity is one major reason for unpredictable therapeutic outcomes, while stratifying therapeutic responses at an early time may greatly benefit the better control of cancer. Here, we developed a hybrid nanovesicle to stratify radiotherapy response by activatable inflammation magnetic resonance imaging (aiMRI) approach. The high Pearson's correlation coefficient R values are obtained from the correlations between the T

Identifiants

DOI: 10.1038/s41467-020-16771-y PMID: 32541769 PMC: PMC7295999
pubmed: 32541769
doi: 10.1038/s41467-020-16771-y
pii: 10.1038/s41467-020-16771-y
pmc: PMC7295999
doi:

Substances chimiques

Reactive Oxygen Species 0

Types de publication

Evaluation Study Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3032

Subventions

Organisme : Intramural NIH HHS
ID : ZIA EB000073
Pays : United States

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Auteurs

Zijian Zhou (Z)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Hongzhang Deng (H)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China.

Weijing Yang (W)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Zhantong Wang (Z)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Lisen Lin (L)

MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China.

Jeeva Munasinghe (J)

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

Orit Jacobson (O)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Yijing Liu (Y)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Longguang Tang (L)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Qianqian Ni (Q)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
ORCID: 0000-0003-4230-5059

Fei Kang (F)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Yuan Liu (Y)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Gang Niu (G)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.

Ruiliang Bai (R)

Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, 310029, China.
ORCID: 0000-0003-4246-5984

Chunqi Qian (C)

Department of Radiology, Michigan State University, East Lansing, MI, 48824, USA.

Jibin Song (J)

MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China. jibinsong@fzu.edu.cn.

Xiaoyuan Chen (X)

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA. shawn.chen@nih.gov.
ORCID: 0000-0002-9622-0870

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Early stratification of radiotherapy response...
questionsmedicales.fr › Eucaryotes › Animaux › Early stratification of radiotherapy response...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Early stratification of radiotherapy response...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Early stratification of radiotherapy response...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Early stratification of radiotherapy response...
questionsmedicales.fr › Tumeurs › Early stratification of radiotherapy response...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Early stratification of radiotherapy response...