The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
02
2020
accepted:
20
05
2020
entrez:
17
6
2020
pubmed:
17
6
2020
medline:
20
8
2020
Statut:
epublish
Résumé
Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in group-housed adult male mice from C57BL/6N substrains. Clinical signs included a sudden onset of mild to severe unilateral or bilateral tarsal abduction, swelling, abnormal hindlimb morphology and lameness. Contraction of digits and gait abnormalities were noted in multiple cases. Radiographical and histological examination revealed caudal dislocation of the calcaneus and partial dislocation of the calcaneoquartal (calcaneus-tarsal bone IV) joint. The detection, frequency, and cause of this pathology in five large mouse production and phenotyping centres (MRC Harwell, UK; The Jackson Laboratory, USA; The Centre for Phenogenomics, Canada; German Mouse Clinic, Germany; Baylor College of Medicine, USA) are discussed.
Identifiants
pubmed: 32542000
doi: 10.1371/journal.pone.0230162
pii: PONE-D-20-05114
pmc: PMC7295225
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0230162Subventions
Organisme : Medical Research Council
ID : MC_UP_1502/1
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : UM1 HG006348
Pays : United States
Organisme : NIH HHS
ID : UM1 OD023221
Pays : United States
Organisme : Medical Research Council
ID : A410
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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