Klotho and vitamin D in multiple sclerosis: an Italian study.
Klotho
genetic
multiple sclerosis
vitamin D
Journal
Archives of medical science : AMS
ISSN: 1734-1922
Titre abrégé: Arch Med Sci
Pays: Poland
ID NLM: 101258257
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
03
2019
accepted:
01
05
2019
entrez:
17
6
2020
pubmed:
17
6
2020
medline:
17
6
2020
Statut:
epublish
Résumé
Low vitamin D levels have been recognised as an important risk factor for autoimmune diseases, including multiple sclerosis (MS). MS is a multifactorial disease, the pathogenesis of which contributes both to genetic and environmental factors. Polymorphisms in genes codifying molecules involved in vitamin D homeostasis have been associated with hypovitaminosis D. However, the influence of polymorphisms of Klotho, which codify a protein with a pivotal role in vitamin D metabolism, have never been investigated. The aim of this study was to evaluate the association among genetic variants of Klotho, namely rs1207568 and rs9536314, serum 25(OH)D 107 patients with MS and 133 healthy controls were enrolled in this study. Serum 25(OH)D Allelic and genotypic frequencies did not differ between patients and controls. Concerning rs1207568, we found a trend toward lower serum 25(OH)D Our findings did not identify a role of Klotho in the genetic susceptibility to MS.
Identifiants
pubmed: 32542086
doi: 10.5114/aoms.2019.86969
pii: 37335
pmc: PMC7286339
doi:
Types de publication
Journal Article
Langues
eng
Pagination
842-847Informations de copyright
Copyright © 2019 Termedia & Banach.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Arch Med Sci. 2017 Jun;13(4):732-737
pubmed: 28721139
Biochem Biophys Res Commun. 2015 Apr 24;460(1):53-71
pubmed: 25998734
Metabolism. 2006 Oct;55(10):1344-51
pubmed: 16979405
Neurol Sci. 2016 Feb;37(2):261-7
pubmed: 26506927
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Arch Med Sci. 2017 Feb 1;13(1):53-60
pubmed: 28144255
Sci Rep. 2018 Apr 30;8(1):6735
pubmed: 29712948
Clin Chim Acta. 2010 Mar;411(5-6):386-90
pubmed: 20005218
Front Endocrinol (Lausanne). 2017 Nov 17;8:323
pubmed: 29250031
Lancet Neurol. 2010 Jun;9(6):599-612
pubmed: 20494325
J Neurol Sci. 2015 Jul 15;354(1-2):27-32
pubmed: 25990800
Nature. 1997 Nov 6;390(6655):45-51
pubmed: 9363890
Mult Scler Relat Disord. 2017 May;14:35-45
pubmed: 28619429
Ann Clin Lab Sci. 2017 Aug;47(4):508-510
pubmed: 28801380
J Clin Endocrinol Metab. 2011 Jan;96(1):53-8
pubmed: 21118827
Clin Chim Acta. 2015 Dec 7;451(Pt B):215-8
pubmed: 26434548
J Mol Neurosci. 2018 Sep;66(1):77-84
pubmed: 30088172
Clin Chim Acta. 2009 Aug;406(1-2):134-8
pubmed: 19539617
Mult Scler. 2011 Dec;17(12):1405-11
pubmed: 21998006
Am J Alzheimers Dis Other Demen. 2015 Dec;30(8):729-32
pubmed: 23823143
Brain Res. 2011 Mar 25;1382:109-17
pubmed: 21276773
Eur Arch Psychiatry Clin Neurosci. 2013 Oct;263(7):553-60
pubmed: 23591828
Endocr Rev. 2015 Apr;36(2):174-93
pubmed: 25695404
J Diabetes Complications. 2016 Jan-Feb;30(1):126-32
pubmed: 26601789
Neurol Genet. 2016 Sep 13;2(5):e97
pubmed: 27652346
Neurology. 2014 Sep 2;83(10):920-8
pubmed: 25098535
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237
PLoS Med. 2015 Aug 25;12(8):e1001866
pubmed: 26305103
Arch Med Sci. 2019 Jan;15(1):113-119
pubmed: 30697260
eNeurologicalSci. 2018 Jan 28;10:37-44
pubmed: 29736427
Arch Med Sci. 2019 Mar;15(2):359-368
pubmed: 30899288
Front Immunol. 2017 Jan 20;7:697
pubmed: 28163705
Clin Chem Lab Med. 2011 May;49(5):897-901
pubmed: 21288172
J Cell Mol Med. 2016 Jan;20(1):128-33
pubmed: 26538295
Ann Neurosci. 2016 Sep;23(3):155-161
pubmed: 27721584
Mult Scler. 2015 Jul;21(8):969-77
pubmed: 25767125
Physiol Rev. 2016 Jan;96(1):365-408
pubmed: 26681795
Arch Med Sci Atheroscler Dis. 2018 Mar 27;3:e60-e67
pubmed: 30775591
Neurology. 2005 Apr 12;64(7):1144-51
pubmed: 15824338
Am J Hyg. 1960 Jul;72:88-99
pubmed: 13791629
Neurol Ther. 2018 Jun;7(1):59-85
pubmed: 29243029
Semin Neurol. 2016 Apr;36(2):103-14
pubmed: 27116717
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):856-61
pubmed: 11792841
Clin Biochem. 2017 Sep;50(13-14):797-803
pubmed: 28456545
Cent Eur J Immunol. 2018;43(3):331-334
pubmed: 30588177
Biochem Genet. 2017 Apr;55(2):183-192
pubmed: 27904983
Age (Dordr). 2016 Feb;38(1):7
pubmed: 26732817
Arch Med Sci. 2018 Jan;14(1):122-131
pubmed: 29379542
J Neurosci Res. 2018 Feb;96(2):297-304
pubmed: 28834557
Scand J Clin Lab Invest. 2017 Oct;77(6):428-432
pubmed: 28650717
Med Chem. 2018 Feb 6;14(2):129-143
pubmed: 28933265
Arch Med Sci. 2019 Mar;15(2):554-557
pubmed: 30899309
Curr Opin Nephrol Hypertens. 2006 Jul;15(4):437-41
pubmed: 16775459
J Neuroimmunol. 2019 Apr 15;329:1-8
pubmed: 29793727
Mult Scler. 2017 Jul;23(8):1123-1136
pubmed: 28273775
Biochem Biophys Res Commun. 1998 Jan 26;242(3):626-30
pubmed: 9464267
Mol Endocrinol. 2003 Dec;17(12):2393-403
pubmed: 14528024