A Case of Extensive Debilitating Generalized Morphea.
chronic pain
immunosuppressants
joint pain
joint restriction
methotrexate
morphea
rare skin disease
restriction of motion
scleroderma
skin biopsy
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
14 May 2020
14 May 2020
Historique:
entrez:
17
6
2020
pubmed:
17
6
2020
medline:
17
6
2020
Statut:
epublish
Résumé
Morphea, also known as localized scleroderma, is an uncommon idiopathic inflammatory disorder leading to the development of sclerotic plaques in the skin. The disorder preferentially affects females. The pathogenesis of morphea is not well-understood. The disorder is likely to have an autoimmune basis; environmental and genetic factors may also play a role in its etiology. Morphea has a variety of clinical presentations. Lesions of morphea typically begin as inflammatory plaques or patches that evolve into firm sclerotic lesions. Involvement may be limited to the dermis or may extend to underlying subcutaneous fat, muscle, or bone. The identification of characteristic clinical findings is often sufficient for the diagnosis of morphea. A biopsy can be a useful tool when the diagnosis is in question or to obtain information on the depth and intensity of the disease, and it should always extend at least into the subcutaneous fat. Morphea may cause joint contractures and other impairments secondary to tissue sclerosis and can be very debilitating cosmetically and functionally.
Identifiants
pubmed: 32542170
doi: 10.7759/cureus.8117
pmc: PMC7292686
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e8117Informations de copyright
Copyright © 2020, Sapra et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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