Fc gamma receptor expression serves as prognostic and diagnostic factor in AML.

Flow Cytometry Humans Immunophenotyping Leukemia, Myeloid, Acute / diagnosis Prognosis Receptors, IgG / genetics
Acute myeloid leukemia CD16 CD32 CD64 Fc gamma receptor risk assessment

Journal

Leukemia & lymphoma
ISSN: 1029-2403
Titre abrégé: Leuk Lymphoma
Pays: United States
ID NLM: 9007422

Informations de publication

Date de publication:
10 2020
Historique:
pubmed: 17 6 2020
medline: 28 4 2021
entrez: 17 6 2020
Statut: ppublish

Résumé

Risk assessment in acute myeloid leukemia (AML) mainly relies on (cyto-)genetic and morphologic features. Nonetheless, further markers are needed to allow for accurate risk stratification. Type I Fc gamma receptors (FcγRs) such as CD16, CD32, and CD64 play an important role in mediating immunomodulatory functions in different myeloid cell types as well as NK and B cells. We here evaluated expression of the three FcγR on peripheral blood AML blasts. Using flow cytometry, we found heterogeneous expression of the FcγR throughout the patient cohort. Correlation of expression levels with disease outcome revealed significantly shorter OS in patients with CD16

Identifiants

DOI: 10.1080/10428194.2020.1775208 PMID: 32543333
pubmed: 32543333
doi: 10.1080/10428194.2020.1775208
doi:

Substances chimiques

Receptors, IgG 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2466-2474

Auteurs

Jonas S Heitmann (JS)

Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), University Hospital Tübingen, Tubingen, Germany.
DFG Cluster of Excellence 2180 'Image-guided and Functional Instructed Tumor Therapy' (IFIT), University of Tübingen, Tübingen, Germany.
ORCID: 0000-0002-7305-8620

Ilona Hagelstein (I)

Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), University Hospital Tübingen, Tubingen, Germany.
DFG Cluster of Excellence 2180 'Image-guided and Functional Instructed Tumor Therapy' (IFIT), University of Tübingen, Tübingen, Germany.

Clemens Hinterleitner (C)

DFG Cluster of Excellence 2180 'Image-guided and Functional Instructed Tumor Therapy' (IFIT), University of Tübingen, Tübingen, Germany.
Department of Medical Oncology and Pulmonology, University Hospital Tubingen, Tübingen, Germany.
ORCID: 0000-0003-2416-9399

Lukas Osburg (L)

Department of Immunology, Interfaculty Institute for Cell Biology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), University of Tübingen, Tübingen, Germany.

Helmut R Salih (HR)

Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), University Hospital Tübingen, Tubingen, Germany.
DFG Cluster of Excellence 2180 'Image-guided and Functional Instructed Tumor Therapy' (IFIT), University of Tübingen, Tübingen, Germany.
ORCID: 0000-0002-6719-1847

Joseph Kauer (J)

Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), University Hospital Tübingen, Tubingen, Germany.
DFG Cluster of Excellence 2180 'Image-guided and Functional Instructed Tumor Therapy' (IFIT), University of Tübingen, Tübingen, Germany.
Department of Immunology, Interfaculty Institute for Cell Biology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), University of Tübingen, Tübingen, Germany.
ORCID: 0000-0003-1632-0167

Melanie Märklin (M)

Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), University Hospital Tübingen, Tubingen, Germany.
DFG Cluster of Excellence 2180 'Image-guided and Functional Instructed Tumor Therapy' (IFIT), University of Tübingen, Tübingen, Germany.
ORCID: 0000-0002-2920-3894

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › Fc gamma receptor expression serves as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fc gamma receptor expression serves as...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › Fc gamma receptor expression serves as...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Fc gamma receptor expression serves as...
questionsmedicales.fr › Diagnostic › Pronostic › Fc gamma receptor expression serves as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteur Fc › Récepteurs du fragment Fc des IgG › Fc gamma receptor expression serves as...