Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations.

Adenylyl Imidodiphosphate / metabolism Animals Chromatin Assembly and Disassembly / genetics Cryoelectron Microscopy Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics Mutation Nucleosomes / metabolism Xenopus laevis
Cryo-EM biochemistry cancer chemical biology chromatin remodelling human molecular biophysics neurodevelopmental disorder structural biology

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
16 06 2020
Historique:
received: 10 03 2020
accepted: 15 06 2020
pubmed: 17 6 2020
medline: 17 2 2021
entrez: 17 6 2020
Statut: epublish

Résumé

Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene repression. Here, we report the cryo-electron microscopy (cryo-EM) structure of

Identifiants

DOI: 10.7554/eLife.56178 PMID: 32543371 PMC: PMC7338049
pubmed: 32543371
doi: 10.7554/eLife.56178
pii: 56178
pmc: PMC7338049
doi:
pii:

Substances chimiques

CHD4 protein, human 0
Nucleosomes 0
Adenylyl Imidodiphosphate 25612-73-1
Mi-2 Nucleosome Remodeling and Deacetylase Complex EC 3.5.1.98

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Research Council
ID : 693023
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB860
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB1064
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : EXC 2067/1-390729940
Pays : International

Informations de copyright

© 2020, Farnung et al.

Déclaration de conflit d'intérêts

LF, MO, PC No competing interests declared

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Auteurs

Lucas Farnung (L)

Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany.
ORCID: 0000-0002-8200-2493

Moritz Ochmann (M)

Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany.

Patrick Cramer (P)

Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen, Germany.
ORCID: 0000-0001-5454-7755

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Adenylyl imidodiphosphate › Nucleosome-CHD4 chromatin remodeler structure...
questionsmedicales.fr › Eucaryotes › Animaux › Nucleosome-CHD4 chromatin remodeler structure...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Nucleosome-CHD4 chromatin remodeler structure...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Nucleosome-CHD4 chromatin remodeler structure...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Complexe Mi-2/NuRD › Nucleosome-CHD4 chromatin remodeler structure...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Nucleosome-CHD4 chromatin remodeler structure...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Nucléosomes › Nucleosome-CHD4 chromatin remodeler structure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › Nucleosome-CHD4 chromatin remodeler structure...