Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains.
arousal
behavioral modeling
bias
decision-making
human
mouse
neuroscience
pupil
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
16 06 2020
16 06 2020
Historique:
received:
04
12
2019
accepted:
21
05
2020
entrez:
17
6
2020
pubmed:
17
6
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Decisions are often made by accumulating ambiguous evidence over time. The brain's arousal systems are activated during such decisions. In previous work in humans, we found that evoked responses of arousal systems during decisions are reported by rapid dilations of the pupil and track a suppression of biases in the accumulation of decision-relevant evidence (de Gee et al., 2017). Here, we show that this arousal-related suppression in decision bias acts on both conservative and liberal biases, and generalizes from humans to mice, and from perceptual to memory-based decisions. In challenging sound-detection tasks, the impact of spontaneous or experimentally induced choice biases was reduced under high phasic arousal. Similar bias suppression occurred when evidence was drawn from memory. All of these behavioral effects were explained by reduced evidence accumulation biases. Our results point to a general principle of interplay between phasic arousal and decision-making.
Identifiants
pubmed: 32543372
doi: 10.7554/eLife.54014
pii: 54014
pmc: PMC7297536
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Commission
ID : 658581-CODIR
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : DO 1240/4-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : DO 1240/3-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 936A7
Pays : International
Organisme : NIDCD NIH HHS
ID : R01 DC017797
Pays : United States
Organisme : NIDCD NIH HHS
ID : R03 DC015618
Pays : United States
Organisme : German National Academy of Sciences Leopoldina
ID : LPDS 2019-03
Pays : International
Organisme : German Academic Exchange Service
ID : A/13/70362
Pays : International
Informations de copyright
© 2020, de Gee et al.
Déclaration de conflit d'intérêts
Jd, KT, LS, AU, DM, MM No competing interests declared, TD Reviewing editor, eLife
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