The utility of multiparametric MRI to characterize hypoxic tumor subvolumes in comparison to FMISO PET/CT. Consequences for diagnosis and chemoradiation treatment planning in head and neck cancer.
Chemoradiation
FMISO
Head-and-neck cancer
Hypoxia
Multiparametric MRI
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
02
04
2020
revised:
02
06
2020
accepted:
10
06
2020
pubmed:
17
6
2020
medline:
15
4
2021
entrez:
17
6
2020
Statut:
ppublish
Résumé
Hypoxia is an essential metabolic marker that determines chemo- and radiation resistance in head-and-neck squamous cell carcinoma (HNSCC) patients. Our exploratory analysis aimed to identify multiparametric MRI (mpMRI) parameters linked to hypoxia that might be used as surrogate for [ 21 patients undergoing definitive CRT for HNSCC were prospectively imaged with serial [ FMISO-PET-based HSVs of the primary tumors on MRI were characterized by lower ADC at all time points (p = 0.012 at baseline; p = 0.015 in week 2) and reduced interstitial space volume fraction v MpMRI parameters differ significantly between hypoxic and non-hypoxic tumor regions, defined on FMISO-PET/CT as gold standard and might represent surrogate markers for tumor hypoxia. These findings suggest that mpMRI may be useful in the future as a surrogate modality for hypoxia imaging in order to personalize CRT.
Sections du résumé
BACKGROUND AND PURPOSE
Hypoxia is an essential metabolic marker that determines chemo- and radiation resistance in head-and-neck squamous cell carcinoma (HNSCC) patients. Our exploratory analysis aimed to identify multiparametric MRI (mpMRI) parameters linked to hypoxia that might be used as surrogate for [
MATERIALS AND METHODS
21 patients undergoing definitive CRT for HNSCC were prospectively imaged with serial [
RESULTS
FMISO-PET-based HSVs of the primary tumors on MRI were characterized by lower ADC at all time points (p = 0.012 at baseline; p = 0.015 in week 2) and reduced interstitial space volume fraction v
CONCLUSION
MpMRI parameters differ significantly between hypoxic and non-hypoxic tumor regions, defined on FMISO-PET/CT as gold standard and might represent surrogate markers for tumor hypoxia. These findings suggest that mpMRI may be useful in the future as a surrogate modality for hypoxia imaging in order to personalize CRT.
Identifiants
pubmed: 32544609
pii: S0167-8140(20)30336-4
doi: 10.1016/j.radonc.2020.06.013
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
fluoromisonidazole
082285VIDF
Misonidazole
8FE7LTN8XE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
128-135Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.