Cytotoxicity and Mutagenicity of Narrowband UVB to Mammalian Cells.
DNA damage
HPRT
SCE
broadband UVB
cytotoxicity
narrowband UVB
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
11 06 2020
11 06 2020
Historique:
received:
05
05
2020
revised:
04
06
2020
accepted:
08
06
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
20
3
2021
Statut:
epublish
Résumé
Phototherapy using narrowband ultraviolet-B (NB-UVB) has been shown to be more effective than conventional broadband UVB (BB-UVB) in treating a variety of skin diseases. To assess the difference in carcinogenic potential between NB-UVB and BB-UVB, we investigated the cytotoxicity via colony formation assay, genotoxicity via sister chromatid exchange (SCE) assay, mutagenicity via hypoxanthine phosphoribosyltransferase (HPRT) mutation assay, as well as cyclobutane pyrimidine dimer (CPD) formation and reactive oxygen species (ROS) generation in Chinese hamster ovary (CHO) and their NER mutant cells. The radiation dose required to reduce survival to 10% (D
Identifiants
pubmed: 32545288
pii: genes11060646
doi: 10.3390/genes11060646
pmc: PMC7349664
pii:
doi:
Substances chimiques
Mutagens
0
Pyrimidine Dimers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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