One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents.
Administration, Oral
Animals
Anti-Inflammatory Agents
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Antioxidants
/ chemical synthesis
Aspirin
/ pharmacology
Carrageenan
/ adverse effects
Cell Line, Tumor
Cell Survival
/ drug effects
Cisplatin
/ pharmacology
Disease Models, Animal
Edema
/ chemically induced
Enzyme Inhibitors
/ chemical synthesis
Humans
Male
Mannich Bases
Mice
Molecular Structure
Quinolines
/ chemical synthesis
alpha-Amylases
/ antagonists & inhibitors
MTT assay
antioxidant
in vivo anti-inflammatory activity
tetrahydroquinoline
α-amylase enzyme inhibition
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Jun 2020
11 Jun 2020
Historique:
received:
26
05
2020
revised:
05
06
2020
accepted:
07
06
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
16
2
2021
Statut:
epublish
Résumé
Mankind has always suffered from multiple diseases. Therefore, there has been a rigorous need in the field of medicinal chemistry for the design and discovery of new and potent molecular entities. In this work, thirteen tetrahydroquinoline derivatives were synthesized and evaluated biologically for their antioxidant, α-amylase enzyme inhibitory, anti-proliferative and anti-inflammatory activities.
Identifiants
pubmed: 32545290
pii: molecules25112710
doi: 10.3390/molecules25112710
pmc: PMC7321408
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antineoplastic Agents
0
Antioxidants
0
Enzyme Inhibitors
0
Mannich Bases
0
Quinolines
0
Carrageenan
9000-07-1
1,2,3,4-tetrahydroquinoline
CCR50N1Z9G
alpha-Amylases
EC 3.2.1.1
Cisplatin
Q20Q21Q62J
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Higher Education Commission, Pakistan
ID : PIN NO. 315-11229-2MD3-036
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