Synthesis and Studies of the Inhibitory Effect of Hydroxylated Phenylpropanoids and Biphenols Derivatives on Tyrosinase and Laccase Enzymes.
Animals
Catalytic Domain
Cell Survival
/ drug effects
Crystallography, X-Ray
Enzyme Inhibitors
/ chemical synthesis
Hydroxylation
Laccase
/ antagonists & inhibitors
Models, Molecular
Monophenol Monooxygenase
/ antagonists & inhibitors
PC12 Cells
Phenol
/ chemistry
Propanols
/ chemical synthesis
Protein Conformation
Rats
Tenebrio
/ drug effects
SAR studies
biosensors
chitin inhibitors
oxidase and polyphenol oxidase
polyphenols
spectrophotometric assay
tyrosinase inhibitors
viability
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Jun 2020
11 Jun 2020
Historique:
received:
16
04
2020
revised:
08
06
2020
accepted:
09
06
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
16
2
2021
Statut:
epublish
Résumé
The impaired activity of tyrosinase and laccase can provoke serious concerns in the life cycles of mammals, insects and microorganisms. Investigation of inhibitors of these two enzymes may lead to the discovery of whitening agents, medicinal products, anti-browning substances and compounds for controlling harmful insects and bacteria. A small collection of novel reversible tyrosinase and laccase inhibitors with a phenylpropanoid and hydroxylated biphenyl core was prepared using naturally occurring compounds and their activity was measured by spectrophotometric and electrochemical assays. Biosensors based on tyrosinase and laccase enzymes were constructed and used to detect the type of protein-ligand interaction and half maximal inhibitory concentration (IC
Identifiants
pubmed: 32545293
pii: molecules25112709
doi: 10.3390/molecules25112709
pmc: PMC7321210
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Propanols
0
Phenol
339NCG44TV
Laccase
EC 1.10.3.2
Monophenol Monooxygenase
EC 1.14.18.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Autonoma della Sardegna
ID : L.R. 7, 2007, CRP 25114
Organisme : Università degli Studi di Sassari
ID : Fondo di Ateneo per la ricerca 2019
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