Gut Microbiome in Psoriasis: An Updated Review.
gut barrier
gut-skin axis
microbiome
psoriasis
systematic review
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
12 Jun 2020
12 Jun 2020
Historique:
received:
08
05
2020
revised:
29
05
2020
accepted:
08
06
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
18
6
2020
Statut:
epublish
Résumé
(1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut-skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The objective of this study was to synthesize current data on the gut microbial composition in psoriasis. (2) Methods: We conducted a systematic review of studies investigating intestinal microbiome in psoriasis, using the PRISMA checklist. We searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2000-2020). (3) Results: All of the 10 retrieved studies reported alterations in the gut microbiome in patients with psoriasis. Eight studies assessed alpha- and beta-diversity. Four of them reported a lack of change in alpha-diversity, but all confirmed significant changes in beta-diversity. At the phylum-level, at least two or more studies reported a lower relative abundance of Bacteroidetes, and higher Firmicutes in psoriasis patients versus healthy controls. (4) Conclusions: There is a significant association between alterations in gut microbial composition and psoriasis; however, there is high heterogeneity between studies. More unified methodological standards in large-scale studies are needed to understand microbiota's contribution to psoriasis pathogenesis and its modulation as a potential therapeutic strategy.
Identifiants
pubmed: 32545459
pii: pathogens9060463
doi: 10.3390/pathogens9060463
pmc: PMC7350295
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : MNiSW/2019/32/DIR/NN4
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Invest Dermatol. 2020 Apr 2;:
pubmed: 32247858
J Dermatol. 2018 Dec;45(12):1468-1470
pubmed: 30222202
Sci Rep. 2018 Mar 23;8(1):5143
pubmed: 29572539
Diseases. 2018 Jun 29;6(3):
pubmed: 29966270
Br J Dermatol. 2019 Aug;181(2):401-402
pubmed: 30729502
BMJ. 2009 Jul 21;339:b2535
pubmed: 19622551
Front Microbiol. 2019 Feb 21;10:236
pubmed: 30846974
Ann Transl Med. 2019 Oct;7(20):571
pubmed: 31807552
Microbiome. 2019 Sep 13;7(1):130
pubmed: 31519223
Eur J Clin Nutr. 2020 Mar 30;:
pubmed: 32231226
Biomed Res Int. 2018 Jan 16;2018:9340316
pubmed: 29682571
J Mol Biol. 2020 Feb 14;432(4):765-785
pubmed: 31857085
Clin Drug Investig. 2019 Dec;39(12):1195-1203
pubmed: 31549347
J Eur Acad Dermatol Venereol. 2019 Oct;33(10):1907-1912
pubmed: 31120609
Exp Dermatol. 2018 Dec;27(12):1336-1343
pubmed: 30238519
Mult Scler Relat Disord. 2020 Jan;37:101427
pubmed: 32172998
Exp Dermatol. 2018 Feb;27(2):144-149
pubmed: 29130553
Cell Host Microbe. 2019 Nov 13;26(5):666-679.e7
pubmed: 31607556
Exp Dermatol. 2019 Nov;28(11):1210-1218
pubmed: 31386766
J Clin Med. 2019 Jul 12;8(7):
pubmed: 31336842
Sci Rep. 2018 Feb 28;8(1):3812
pubmed: 29491401
BMC Microbiol. 2017 Jan 21;17(1):23
pubmed: 28109256
Food Nutr Res. 2019 Feb 14;63:
pubmed: 30814920
Clin Chem Lab Med. 2020 Feb 25;58(3):340-349
pubmed: 31494628
J Eur Acad Dermatol Venereol. 2009 Aug;23(8):957-8
pubmed: 19368618
Br J Dermatol. 2019 Dec;181(6):1287-1295
pubmed: 30920647
Curr Obes Rep. 2019 Sep;8(3):317-332
pubmed: 31175629
PLoS One. 2016 Jul 19;11(7):e0159539
pubmed: 27434104
Zhonghua Nei Ke Za Zhi. 2019 Oct 1;58(10):782-785
pubmed: 31594178
Clin J Gastroenterol. 2018 Feb;11(1):1-10
pubmed: 29285689
PLoS One. 2020 Jan 29;15(1):e0227147
pubmed: 31995569
Am J Transl Res. 2016 Dec 15;8(12):5672-5684
pubmed: 28078038
Mol Psychiatry. 2020 Jan 27;:
pubmed: 31988436
Arthritis Rheumatol. 2016 Jan;68(1):35-45
pubmed: 26331579
Sci China Life Sci. 2019 Jun;62(6):807-815
pubmed: 30264198
Clin Sci (Lond). 2018 Jan 11;132(1):85-91
pubmed: 29326279
Med Hypotheses. 2017 Jan;98:35-37
pubmed: 28012600
J Crohns Colitis. 2016 Sep;10(9):1067-75
pubmed: 26971052
Immunity. 2019 Aug 20;51(2):225-239
pubmed: 31433970
Am J Gastroenterol. 2019 Jul;114(7):1051-1070
pubmed: 31232832
J Dermatol. 2019 Jul;46(7):595-603
pubmed: 31141234
Cell Host Microbe. 2019 Mar 13;25(3):444-453.e3
pubmed: 30799264
Front Med (Lausanne). 2018 Dec 14;5:349
pubmed: 30619860
Pediatr Res. 2019 May;85(6):895-903
pubmed: 30758325
Gastroenterology. 2020 Mar;158(4):930-946.e1
pubmed: 31812509
J Autoimmun. 2020 Feb;107:102360
pubmed: 31806420
Arthritis Rheumatol. 2015 Jan;67(1):128-39
pubmed: 25319745
Br J Dermatol. 2020 Apr;182(4):840-848
pubmed: 31225638
Exp Mol Med. 2018 Aug 16;50(8):103
pubmed: 30115904
Front Microbiol. 2018 May 22;9:1037
pubmed: 29872428