The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections.
antibiotic resistance
diterpenes
multidrug-resistant strains.
plant secondary metabolites
plant-derived natural products
terpenes
triterpenes
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
13 Jun 2020
13 Jun 2020
Historique:
received:
18
05
2020
revised:
03
06
2020
accepted:
10
06
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
18
6
2020
Statut:
epublish
Résumé
The discovery of antibiotics has revolutionized the medicine and treatment of microbial infections. However, the current scenario has highlighted the difficulties in marketing new antibiotics and an exponential increase in the appearance of resistant strains. On the other hand, research in the field of drug-discovery has revaluated the potential of natural products as a unique source for new biologically active molecules and scaffolds for the medicinal chemistry. In this review, we first contextualized the worldwide problem of antibiotic resistance and the importance that natural products of plant origin acquire as a source of new lead compounds. We then focused on terpenes and their potential development as antimicrobials, highlighting those studies that showed an activity against conventional antibiotic-resistant strains.
Identifiants
pubmed: 32545761
pii: antibiotics9060325
doi: 10.3390/antibiotics9060325
pmc: PMC7344648
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : PON, Piano Operativo Nazionale
ID : ARS01_00432 PROGEMA, "Processi Green per l'Estrazione di Principi Attivi e la Depurazione di Matrici di Scarto e Non", 03/2018-09/2020
Organisme : PRIN 2017
ID : -"Targeting Hedgehog pathway: Virtual screening identification and sustainable synthesis of novel Smo and Gli inhibitors and their pharmacological drug delivery strategies for improved therapeutic effects in tumors" by the Italian Ministry of Education, U
Organisme : MIUR- Dipartimenti di Eccellenza
ID : L. 232/2016
Organisme : Sapienza Università di Roma
ID : RM11816436113D8A
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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