Hepatitis in children with tuberculosis: a case report and review of the literature.
Children
Hepatitis
Liver function tests; hepatic tuberculosis
Transaminases
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
16 Jun 2020
16 Jun 2020
Historique:
received:
28
02
2020
accepted:
11
06
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment. We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a literature review for TB-associated hepatitis in children. Liver function tests should be considered, when feasible, in infants and young children with pulmonary TB. Testing could help to identify and manage patients with TB-associated hepatic abnormalities, and also to establish a baseline for detection and management of liver injury associated with anti-TB therapy.
Sections du résumé
BACKGROUND
BACKGROUND
Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment.
CASE PRESENTATION
METHODS
We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a literature review for TB-associated hepatitis in children.
CONCLUSIONS
CONCLUSIONS
Liver function tests should be considered, when feasible, in infants and young children with pulmonary TB. Testing could help to identify and manage patients with TB-associated hepatic abnormalities, and also to establish a baseline for detection and management of liver injury associated with anti-TB therapy.
Identifiants
pubmed: 32546255
doi: 10.1186/s12890-020-01215-6
pii: 10.1186/s12890-020-01215-6
pmc: PMC7298953
doi:
Substances chimiques
Antitubercular Agents
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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