Liposomal Encapsulated Curcumin Effectively Attenuates Neuroinflammatory and Reactive Astrogliosis Reactions in Glia Cells and Organotypic Brain Slices.
Animals
Anti-Inflammatory Agents
/ pharmacology
Astrocytes
/ drug effects
Brain
/ drug effects
Cell Line
Cell Survival
/ drug effects
Curcumin
/ pharmacology
Gliosis
/ drug therapy
Humans
Inflammation
/ drug therapy
Lipopolysaccharides
/ pharmacology
Liposomes
Mice
Microglia
/ drug effects
Neuroglia
/ drug effects
brain implants
glial scar
nanoparticles
neuroinflammation
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
01
2020
accepted:
18
04
2020
entrez:
18
6
2020
pubmed:
18
6
2020
medline:
31
7
2020
Statut:
epublish
Résumé
The polyphenolic spice and food coloring ingredient curcumin has beneficial effects in a broad variety of inflammatory diseases. Amongst them, curcumin has been shown to attenuate microglia reaction and prevent from glial scar formation in spinal cord and brain injuries. We developed a protocol for the efficient encapsulation of curcumin as a model for anti-inflammatory drugs yielding long-term stable, non-toxic liposomes with favorable physicochemical properties. Subsequently, we evaluate the effects of liposomal curcumin in experimental models for neuroinflammation and reactive astrogliosis. We could show that liposomal curcumin can efficiently reduce the reactivity of human microglia and astrocytes and preserve tissue integrity of murine organotypic cortex slices. In perspective, we want to administer this curcumin formulation in brain implant coatings to prevent neuroinflammation and glial scar formation as foreign body responses of the brain towards implanted materials.
Identifiants
pubmed: 32547020
doi: 10.2147/IJN.S245300
pii: 245300
pmc: PMC7259452
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Lipopolysaccharides
0
Liposomes
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3649-3667Informations de copyright
© 2020 Schmitt et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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